COAGULATION INDICES OF URINE IN COMPLEX TREATMENT OF EXPERIMENTAL NEPHRITIS

Abstract

THE AIM of the investigation was to study the coagulation indices of urine in treatment of experimental Masuginephritis. MATERIALS AND METHODS. The investigation was performed in rabbits with body mass 2.03.7 kg. Pro and anticoagulatory as well as fibrinolytic properties of urine of healthy and sick animals were studied before and after treatment of the latter with a complex of drugs (plasma with high content of antithrombinIII, prodectin and phentalamine hydrochloride). The silicone, koalin time, partly activated thromboplastine time, index of the contact activation range, prothrombin, thrombin and heparine time, antithrombinIII, fibrinogen/fibrin degradation products (FDP) in urine, enzymatic and nonenzymatic fibrinolysis were determined. RESULTS. It has been found that treatment of Masuginephritis with a complex of drugs decreases activity of factors involved in formation of prothrombinase, the content of FDP in urine, heparin and ATIII, increases activity of both enzymatic and non enzymatic fibrinolysis, i.e. reestablishes the coagulatory potential of urine substantially impaired during the pathological process in the kidneys. CONCLUSION. The diseased kidneys change the pro, anticoagulatory and fibrinolytic indices of urine which become normal after the treatment of experimental nephritis with the complex of drugs (plasma with high content of antithrombin III, prodectin and phentalamine hydrochloride). The coagulation indices of urine can be used for the diagnosing of the development of kidney diseases as well as for control of effectiveness of the therapy.