CLINICO-FUNCTIONAL STATE OF THE KIDNEYS AND ANEMIA IN PATIENTS WITH CHRONIC HEART FAILURE
https://doi.org/10.24884/1561-6274-2007-11-2-45-49
Abstract
THE AIM of the investigation was to study the clinic-functional state of the kidneys, prevalence and severity of anemia among patients with chronic heart failure (CHF). PATIENTS AND METHODS. In 77 patients (mean age 60.4±1.2 years) with CHF I-IV FC (NYHA, 1994) an assessment of the filtration function of the kidneys by the glomerular filtration rate (GFR) was made using the Cockroft-Gault formula, activity of N – acetyl – β – D - hexoaminidase in (NAH) the morning portion of urine – as an index of functional activity of tubules. The presence of microalbuminuria (MAU) was determined that reflected the function of the endothelium and the glomerular apparatus as a whole. The presence of anemia was established by the conventional criteria. RESULTS. A reliably elevated hexoaminidase is characteristic of low FC CHF (FC I-II). At the initial stages of CHF the patients demonstrate the inconsiderably decreased GFR, during progressing of CHF the filtration is considerably decreased and simultaneously MAU is growing. The concentration of blood hemoglobin and hematocrit index is also decreasing with progression of CHF. Anemia is of iron-redistributing character. No association of the concentration of hemoglobin and indices of the functional state of the kidneys was found. CONCLUSION. Hexoaminidase is a marker of early lesion of the tubular apparatus of the kidneys. The tubular lesion in CHF patients precedes the glomerular injury of the kidneys. The presence of anemia in patients is associated with the degree of CHF.
About the Authors
L. T. Pimenov
Ижевская государственная медицинская академия, г. Ижевск, Удмуртия;
Республиканский клинико-диагностический центр, г. Ижевск, Удмуртия
Russian Federation
Russian Federation
N. S. Kirshina
Ижевская государственная медицинская академия, г. Ижевск, Удмуртия;
Республиканский клинико-диагностический центр, г. Ижевск, Удмуртия
Russian Federation
Russian Federation
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Review
For citations:
Pimenov L.T., Kirshina N.S. CLINICO-FUNCTIONAL STATE OF THE KIDNEYS AND ANEMIA IN PATIENTS WITH CHRONIC HEART FAILURE. Nephrology (Saint-Petersburg). 2007;11(2):45-49. (In Russ.) https://doi.org/10.24884/1561-6274-2007-11-2-45-49
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