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ЛЕПТИН – НОВЫЙ ГОРМОН ЖИРОВОЙ ТКАНИ: ЗНАЧЕНИЕ В РАЗВИТИИ ОЖИРЕНИЯ, ПАТОЛОГИИ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ И ПОЧЕК

https://doi.org/10.24884/1561-6274-2005-9-1-9-19

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Аннотация

Лептин новый гормон жировой ткани: значение в развитии ожирения, патологии сердечнососудистой системы и почек.

Об авторах

А. Г. Кучер
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия
Кафедра пропедевтики внутренних болезней


А. В. Смирнов
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия
Кафедра пропедевтики внутренних болезней


И. Г. Каюков
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия
Кафедра пропедевтики внутренних болезней


В. А. Добронравов
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия
Кафедра пропедевтики внутренних болезней


А. А. Яковенко
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия
Кафедра пропедевтики внутренних болезней


Список литературы

1. Панков ЮА. Все органы, ткани и клетки животных и человека являются эндокринными. Вестник РАМН 2001;5:14 19

2. Kennedy G. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc London 1953;140:578 592

3. Hervey G. The effects of lesions in the hypothalamus in parabiotic rats. J Physiol 1959;145:338352

4. Coleman G, Hummel K. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 1969;217:1298 1304

5. Coleman G. Effects of parabiosis with diabetes and normal mice. Diabetologia 1973;9: 294298

6. Zhang Y, Proenca R, Maffei M et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1995;372:425432

7. Kershaw ES, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89(6):25482556

8. Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000;21:697738

9. Fain JN, Madan AK, Hiler ML et al. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissue of obese humans. Endocrinology 2004;145:2273 2282

10. Wiecek A, Kokot F, Chudek J, Adamczak M. The adipose tissue – a novel endocrine organ of interest to the nephrologists. Nephrol Dial Transplant 2002;17(2):191195

11. Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002;26:14071433

12. Tartaglia LA, Dembski M, Weng X et al. Identification and expression cloning of a leptin receptor, OBR. Cell 1995;83:12631271

13. Chen H, Charlat O, Tartaglia LA et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996;84:491495

14. Lee GH, Proenca R, Montez JM et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379:632 635

15. Bjorback C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004;59:305331

16. Le Cava A, Alviggi C, Matarese G. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med 2004;82(1):411

17. SerradeilLe Gal C, Raufaste D, Brossard G et al. Characterization and localization of leptin receptors in the rat kidney. FEBS Lett 1997;404:185191

18. Wolf G, Hamann A, Han DC et al. Leptin stimulates proliferation and TGFІ expression in renal glomerular endothelial cells: potential role in glomerulosclerosis. Kidney Int 1999;56(3):860872

19. Панков ЮА. Лептин – новый гормон в эндокриноло гии. Успехи физиологических наук 2003;34(2):320

20. Zeibel RL. The role of leptin in the control of body weight. Nutrition Reviews 2002;60 (10, pt2):s15s19

21. Rosenbaum M, Nicolson M, Hirsch J et al. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996;81:3424 3427

22. Horlick M, Rosenbaum M, Nicolson M et al. Effect of puberty on the relationship between circulating leptin and body composition. J Clin Endocrinol Metab 2000;85:25092518

23. Harmelen VV, Reynisdottir S, Eriksson P et al. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998;47:913917

24. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000;62:413437

25. Rosenbaum M, Pietrobelli A, Vasselli J et al. Sexual dimorphism in circulating leptin concentrations is not accounted for by dimorphism in adipose tissue distribution. Int J Obes 2001;25:13651371

26. Bjorback C, Elmquist JK, Frantz JD et al. Identification of SOCS3 as a potential mediator of central leptin resistance. Mol Cell 1998;1:619625

27. Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004;116:337350

28. Havel PJ. Role of adipose tissue in body – weight regulation: mechanisms regulating leptin production and energy balance. Proc Nutr Soc 2000;59:359371

29. Hall JE, Crook ED, Jones DW et al. Mechanisms of obesity – associated cardiovascular and renal disease. Am J Med Sciences 2002;324:127137

30. Jequier E. Leptin signaling. Cellular Signaling 2002;14:655663

31. Hayness WG, Morgan DA, Walsh SA et al. Receptor mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997;100:270278

32. Unger RH, Orci L. Lipoapoptosis: its mechanism and its diseases. Biochem Biophys Acta 2002;1585:202212

33. Wang J, Obici S, Morgan K et al. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 2001;50:2786 2791

34. Trayhurn P, Duncan JS, Hoggard N, Rayner DV. Regulation of leptin production: a dominant role for the sympathetic nervous system. Proc Nutr Soc 1998;57:413419

35. Evans BA, Agar L, Summers RJ. The role of the sympathetic nervous system in the regulation of leptin of leptin synthesis in C57BL/6 mice. FEBS Letters 1999;444:149154

36. Eikelis N, Schlaich M, Aggarwal A et al. Interactions between leptin and the human sympathetic nervous system. Hypertension 2003;41:10721079

37. Matsumura K, Abe I, Tsuchihashi T, Fujishima M. Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits. Am J Physiol Regulatory Integrative Comparative Physiol 2000;278:R1314R1320

38. Shirasaka T, Takasaki M, Kannan H. Cardivascular effects of leptin and orexins. Am J Physiol Regulatory Integrative Comparative Physiology 2003;284:R639R651

39. Satoh N, Ogawa Y, Katsuura G. et al. Sympathetic activation of leptin via the ventromedial hypothalamus: leptin induced increase in catecholamine secretion. Diabetes 1999;48:17871793

40. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998;31:409414

41. Kimura K, Tsuda K, Baba A. et al. Involvement of nitric oxide in endotheliumdependent arterial relaxation by leptin. Biochem Biophysic Res Commun 2000;273:745749

42. Quehenberger P, Exner M, SunderPlassmann R et al. Leptin induces endothelin1 in endothelial cells in vitro. Circul Res 2002;90:711718

43. Vecchione C, Maffei A, Colella S et al. Leptin effect on endothelial nitric oxide is mediated through Aktendothelial nitric oxide synthase phosphorylation pathway. Diabetes 2002;51:168173

44. Nakagawa K, Higashi Y, Sasaki S. et al. Leptin causes vasodilatation in humans. Hypertension Research 2002;25:161 165

45. Fruhbeck G. Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes 1999;48:903908

46. Narkiewicz K, Somers VK, Mos L et al. An independent relationship between plasma leptin and heart rate in untreated patients with essential hypertension. J Hypertension 1999;17:245249

47. Sowers JR. Obesity and cardiovascular disease. Clin Chem 1998;44:18211825

48. Ren J. Leptin and hyperleptinemia from friend to foe for cardiovascular function. J Endocrinol 2004;181(1):110

49. Winnicki M, Phillips BG, Accurso V et al. Independent association between plasma leptin levels and heart rate in heart transplant recipients. Circulation 2001;104:384386

50. Singhal A, Faroogi IS, Cole TJ et al. Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 2002;106:19191924

51. Parhami F, Tintut Y, Ballard A et al. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circ Res 2001;88:954960

52. Konstantinides S, Schafer K, Kaschnick S, Zoskutoff DJ. Leptindependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001;8:15331540

53. Winnicki M, Somers VK, Accurs V et al. Fishrich diet, leptin and body mass. Circulation 2002;106(3):289291

54. Bjorback C, ElHaschimi K, Frantz JD, Flier JS. The role of SOCS3 in leptin signaling and leptin resistance. J Biol Chem 1999;274:3005930065

55. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997;46:310

56. Wang J, Liu R, Liu L et al. The effect of leptin on Lep expression is tissuespecific and nutritionally regulated. Nature Med 1999;5:895899

57. Mark AL., Correria ML, Rahmouni K, Haynes WG. Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hyper 2002;20:12451250

58. Kobot F, Chudek J, Adamczak M, Wiecek A. Interrelationship between plasma leptin concentration and severity of metabolic acidosis in hemodialysed patients with chronical renal failure. Exp Clin Endocrinol Diabetes 2001;109(7):370373

59. Stenvinkel P, Heimburger O. The Enigma of increasing serum leptin levels during peritoneal dialysis. Am J Kidn Dis 1999;34(5):947950

60. Merabet E, DagogoJack S, Coyne DW et al. Increased plasma leptin concentration in endstage renal disease. J Clin Endocrinol Metab 1997;82:847850

61. Cumin F, Baum HP, Levens N. Mechanism of leptin removal from the circulation by the kidney. J Endocrinol 1997;155:577585

62. Meyer C, Roson D, Rackovsky N et al. Role of the kidney in human leptin metabolism. Am J Physiol 1997;273:E903E907

63. Wolf G, Hamann A, Han DC et al. Leptin stimulates proliferation and TGFІ expression in renal glomerular endothelial cells: potential role in glomerulosclerosis. Kidney Int 1999;56(3):860872

64. Kambham N, Markowitz GS, Valeri AM et al. Obesity related glomerulopathy: an emerging epidemic. Kidney Int 2001;59:14981509

65. Praga M, Hernandez E, Morales E et al. Clinical features and longterm outcome of obesityassociated focal segmental glomerulosclerosis. Nephrol Dial Transplant 2001;16:17901798

66. Bonnet F, Deprele C, Sassolas A et al. Excessive body weight as a new independent risk factor for clinical and pathological progression in primary IgA nephritis. Am Kidney Dis 2001;37:720727

67. MeierKrische HU, Arndorfer JA, Kaplan B. The impact of body mass index on renal transplant outcomes: a significant independent risk factor for graft failure and patient death. Transplantation 2002;73:7074

68. Morales E, Valero A, Leon M et al. Benefical effects of weight loss in overweight patients with chronic proteinuric nephropathies. Am J Kidney Dis 2003;41:319327

69. Wolf G. After all those fat years: renal consequences of obesity. Nephrol Dial Transplant 2003;18(12):24712474

70. Han DC, Isono M, Chen S et al. Leptin stimulates type I collagen production in db/db mesangial cells: glucose uptake and TGFІ type II receptor expression. Kidn Int 2001;59(4):1315 1323

71. Zhao AZ, Bornfeldt KE, Beavo JA. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest 1998;102:869873

72. Isono M, Mogyorosi A, Han DC et al. Stimulation of TGFІ type II receptor by high glucose in mouse mesangial cell and in diabetic kidney. Am J Physiol 2000;278:F830F838

73. Kasiske BL, Crosson T. Renal disease in patients with massive obesity. Arch Intern Med 1986;146:11051109

74. Bossola M, Muscaritoli M, Valenza V et al. Anorexia and serum leptin levels in hemodialysis patients. Nephrol Clinical Practice 2004;97(3):7682

75. Kokot F, Adamczak M, Wiecek A. Plasma leptin concentration in kidney transplant patients during the early posttransplant period. Nephrol Dial Transplant 1998;13:2276 2280

76. Shoji T, Nishizawa Y, Emoto M et al. Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM. Diabetologia 1997;40:678679

77. Howard JK, Lord GM, Clutterback EJ et al. Plasma immunoreactive leptin concentration in endstage renal disease. Clin Sci Colch 1997;93:119126

78. Young GA, Woodrow G, Kendall S et al. Increased plasma leptin fat ratio in patients with chronic renal failure: it cause of malnutrition? Nephrol Dial Transplant 1997;12:23182323

79. Iida N., Murakami T., Yamada M. et al. Hyperleptinemia in chronic renal failure. Horm Metab Res 1996;28:724727

80. Heimburger O, Lonngvist F, Danielsson et al. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. J Am Soc Nephrol 1997;8:14231430

81. Nakazono H, Nagake Y, Ichikawa H et al. Serum leptin concentrations in patients on hemodialysis. Nephron 1998;80:3540

82. Nishizawa Y, Shoji T, Tanaka S et al. Plasma leptin level and its relationship with body composition in hemodialysis patients. Am J Kidney Dis 1998;31:655661

83. Cumin F, Baum HP, Levens N. Leptin is cleared from the circulation primary by the kidney. Int J Obes Relat Metab Disord 1996;20:11201126

84. Perez Fontan M, RodriguezCarmona A, Cordido F et al. Hyperleptinemia in uremic patients undergoing conservative management, peritoneal dialysis and hemodialysis: A comparative analysis. Am J Kidney Dis 1999;34(5):824831

85. Kagan A, Haran N, Leschinsky L et al. Leptin in CAPD patients: Serum concentrations and peritoneal loss. Nephrol Dial Transplant 1999;14:400405

86. DagogoJack S. Uremic hyperleptinemia: Adaptive or maladaptive. Kidn Int 1998;54:997998

87. Wiesholzer M, Harm F, Hauser AC et al. Inappropriately plasma leptin levels in obese hemodialysis patients can be reduced by high flux haemodialysis and haemofiltration. Clin Sci Colch 1998;94:431435

88. Wideroe TE, Smeby L, Myking O. Plasma concentrations and transperitoneal transport of native insulin and Cpeptide in patients on continuous ambulatory peritoneal dialysis. Kidney Int 1984;25:.8287

89. Wang J, Liu R, Hawkins M et al. A nutrientsensing pathway regulates leptin expression in muscle and fat. Nature 1998;393:684688

90. Tsujimoto Y, Shoji T, Tabata T et al. Leptin in peritoneal dialysate from CAPD patients. Am J Kidney Dis 1999;34:823 838

91. Fongue D, Juillard L, Lasne Y et al. Acute leptin regulation in endstage failure: The role of growth hormone and IFG1. Kidney Int 1998;54:932937

92. Garibotti G, Russo R, Franceschini R et al. Interorgan leptin exchange in humans. Biochem Biophys Res Commun 1998;247:504509

93. Mamoun AH. Anorexia in patients with chronic renal failure: Progress towards understanding the molecular basis. Nephrol Dial Transplant 1998;13:24602463

94. PlataSalaman CR. Leptin and anorexia in renal insufficiency. Nephron Clinical Practice 2004;97(3):7375

95. Yohansen KL, Mulligan K, Tai V et al. Leptin, body composition, and indices of malnutrition in patients on dialysis. J Am Soc Nephrol 1998;9:10801084

96. Don BR, Rosales LM, Levine NW et al. Leptin is a negative acute phase protein in chronic hemodialysis patients. Kidney Int 2001;59:11141120

97. Stenvinkel P, Lindholm B, Lonngvist F et al. Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J Am Soc Nephrol 2000;1:13031309

98. Odamaki M, Furuga R, Yoneyata T et al. Association of the serum leptin concentration with weight loss in chronic hemodialysis patients. Am J Kidney Dis 1999;33:361368

99. Savage DB, O’Rahilly S. Leptin: a novel therapeutic role in lipodystrophy. J Clin Invest 2002;109(10):12851286

100. Mantzoros CS, Flijer JS. Editorial: Leptin as a therapeutic agenttrials and tribulations. J Clin Endocrinol Metabol 2000;85(11):40004002

101. Ahima R, Osei SY. Editorial: Leptin and appetite control in lipodistrophy. J Clin Endocrinol Metab 2004;89(9):42544257

102. Fujioka K, Patane J, Lubina J, Lau D. CSF leptin levels after exogenous administration of recombinant methionyl human leptin. J Am Med Assoc 1999;282:15171518

103. Faroogi IS, Jebb SA, Langmack G et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879884

104. Heymsfield SB, Greenberg AS, Fujioka K et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, doseescalation trial. JAMA 1999;282:15681575

105. Hukshorn CJ, Saris WHM, WesterterPlantenga MC et al. Weekly subcutaneous pegylated recombinant native human leptin (PEGOB) administration in obese men. J Clin Endocrinol Metab 2000;46:249256

106. Konstantinides S, Schafer K, Loskutoff DJ. The prothrombotic effects leptin possible implications for the risk, of cardiovascular disease in obesity. Ann N Y Acad Sci 2001;947:134141

107. Quehenberger P, Exner M, SunderPlassmann R et al. Leptin induces endothelin1 in endothelial cells in vitro. Circ Res 2002;90:711718

108. Garg A. Lipodystrophies. Am J Med 2000;108:143 152

109. Oral EA, Simha V, Ruiz E et al. Leptinreplacement therapy for lipodystrophy. N Engl J Med 2002;346:570578

110. Petersen KF, Oral EA, Dufour S et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Cli Invest 2002;109:134 51350


Для цитирования:


Кучер А.Г., Смирнов А.В., Каюков И.Г., Добронравов В.А., Яковенко А.А. ЛЕПТИН – НОВЫЙ ГОРМОН ЖИРОВОЙ ТКАНИ: ЗНАЧЕНИЕ В РАЗВИТИИ ОЖИРЕНИЯ, ПАТОЛОГИИ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ И ПОЧЕК. Нефрология. 2005;9(1):9-19. https://doi.org/10.24884/1561-6274-2005-9-1-9-19

For citation:


Kucher A.G., Smirnov A.V., Kayukov I.G., Dobronravov V.A., Yakovenko A.A. LEPTIN - A NEW ADIPOSE TISSUE HORMONE: SIGNIFICANCE IN THE DEVELOPMENT OF OBESITY, DISEASES OF THE CARDIOVASCULAR SYSTEM AND KIDNEYS. Nephrology (Saint-Petersburg). 2005;9(1):9-19. (In Russ.) https://doi.org/10.24884/1561-6274-2005-9-1-9-19

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