SPECIFIC EFFECTS OF HE NE LASER IRRADIATION N MECHANICAL ACTIVITY AND RHYTHMOINOTROPIC RELATIONS IN THE MYOCARDIUM OF RATS GIVEN WATER WITH DIFFERENT CONTENT OF MINERAL SUBSTANCES

THE AIM of the study was to perform a comparative investigation of effects of the low power laser irradiation (LPLI) with the wave length 632,2 nm on mechanical activity of cardiomyocytes of rats given definitive feeding. MATERIAL AND METHODS. An analysis of effects of LPLI on contractility of the myocardium of rats given water with normal and low content of calcium and magnesium under conditions of isometric and physiological regimens of mechanical loads. RESULTS. The rats given water with the normal content of calcium (125 mg/l) and magnesium (45 mg/l) demonstrated increased contractility of the myocardium followed by a relaxation at all endsystolic lengths as compared with the parameters registered in the animals with the low content of calcium and magnesium (Petersburg urban water). LPLI caused an increased contractility of the myocardium and growth of the relaxation rate in the rats with a relatively low mechanical activity (animals given the Petersburg urban water) and did not influence the contractility of the myocardium of the rats characterized by a relatively high initial mechanical activity (given water with the normal content of calcium and magnesium). CONCLUSION. The results of the investigation have shown that the continuous consumption by rats of water with normal content of Ca and Mg, in in vivo experiments and a direct irradiation of the myocardium of rats given water with the normal content of Ca and Mg, LPLI experiments in vitro, give the same effect. The myocardium mechanical activity is recovered providing the classical dependence frequency. In addition, LPLI does not appear to change the optimal characteristics of both the myocardium mechanical activity and the rhythm inotropic relations in the rats given water with normal content of Ca and Mg. Evidently, the myocardium of these animals is characterized by activation of the processes of Ca+2 transport responsible for the effect of the action of HeNe laser.

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