Micro and macroelements status in patients on chronic hemodialysis
Abstract
THE AIM. To examine content of essential microelements (zinc (Zn), ferrum) and macroelements magnium (Mg), calcium in biological media in patients with program hemodialysis. PATIENTS AND METHODS: 20 healthy persons and 66 patients (group 1 - 31 patients with diuresis and group 2 - 35 patient without urination) treated by chronic bicarbonate standard hemodialysis. Mg, Zn, Fe, Ca level in blood and urine were measured before and after hemodialysis by atomic absorption spectrophotometry method. RESULT. Patients had significantly lower level not only Ca and Fe, but Zn (22,8±0,84 vs 17,6±0,34 мкг/мл) and Mg (22,8±0,84 vs 18,8±0,344 мкг/мл), the level of elements significantly decreased after dialysis procedure. In group 1 Mg and Zn level in blood were significantly lower (17,1±0,31 и 19,2±0,34 and 1,31±0,091 vs 1,49±0,11 ml/min). In comparison to healthy people 1 group had increased level of Mg and Zn excretion, clearance (2,95±0,39 vs 6,03±0,56 ml/min, p<0,01; (0,29±0,03 vs 0,57±0,029 ml/min, p<0,001) and excretion fraction (0,927±0,031 vs 0,718±0,019, p<0,001; 2,62±0,37 vs 4,95±0,33 mcg/ ml, p<0,01). Statistical analysis showed Mg inverse correlation with age, albumin and Ca level, direct correlation with PTH (p<0,05). CONCLUSION. Hemodialysis patients has not only Ca and Fe, but Mg and Zn deficit. Patients with urination has deeper level of Mg and Zn deficit; Mg correlates with age, Ca, P, PTH level.
About the Authors
E. V. Makarov
«Клиника современной медицины HD»
Russian Federation
Russian Federation
I. D. Shakirov
«Клиника современной медицины HD»
Russian Federation
Russian Federation
A. N. Maksudova
Казанский государственный медицинский университет
Russian Federation
Russian Federation
V. S. Valiev
Институт проблем экологии и недропользования Академии наук Республики Татарстан
Russian Federation
Russian Federation
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Review
For citations:
Makarov E.V., Shakirov I.D., Maksudova A.N., Valiev V.S. Micro and macroelements status in patients on chronic hemodialysis. Nephrology (Saint-Petersburg). 2014;18(1):68-73. (In Russ.)
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