EFFECTS OF SUCCINIC ACID ON KIDNEY FUNCTION IN CHILDREN EXPOSED TO CHRONIC IONIZING RADIATION

Abstract

THE AIM of the work was to investigate effects of using succinic acid in the complex sanatoriumresort rehabilitation on the state of renal mechanisms of regulation of watersalt metabolism according to the results of functional probes of the kidneys of children living under conditions of chronic exposure to ionizing radiation. PATIENTS AND METHODS. The investigation included examination of 15 children aged from 8 to 14 years living on the territory of Ukranian Polesie under conditions of unfavorable radiation situation. The group of comparison consisted of practically healthy schoolchildren of the city of Odessa undergoing the planned course of healthimprovement rehabilitation. RESULTS. Within 14 days after taking succinate the tendency to reduction of the induced diuresis volume and increased osmolality of urine retained against the background of inconsiderably less excretion of osmotically active substances. The excretion of protein reliably reduced as compared both with the initial values and with the analogous index obtained in 7 days after taking the succinic acid. CONCLUSION. The children living in ecologically unfavorable regions in 14 days after taking succinate demonstrated considerably better state of the kidney functions under condition of the watersalt load that can be concluded on the basis of the data of the investigation of renal excretion of mineral substances.