THE INFLUENCE OF SPIRONOLACTONE THERAPY ON THE LEVEL OF ALDOSTERONE AND DYSFUNCTION OF THE ENDOTHELIUM IN PROGRAMMED HEMODIALYSIS PATIENTS
https://doi.org/10.24884/1561-6274-2007-11-2-55-58
Abstract
THE AIM of the investigation was to assess the influence of spironolactone therapy on the level of blood aldosterone and state of the epithelium functioning in program hemodialysis patients with V stage chronic kidney disease (CKD). PATIENTS AND METHODS. In examination of 83 program hemodialysis patients with V stage CKD the following parameters were studied: the level of blood plasma aldosterone, the functional state of the epithelium assessed using biochemical markers - 1 type plasminogen activator inhibitor (PAI-1), tissue plasminogen activator (t-PA), endothelin-1 before and after a 6-month course of spironolactone therapy. RESULTS. All the patients initially had a considerably elevated level of blood aldosterone - 478±99.96 pg/ml (norm – up to 160pg/ml). Against the background of spironolactone therapy a considerably decreased level of aldosterone to 346.45±58.1 pg/ml (p=0.009) was noted and a considerably decreased activity of the endothelium dysfunction markers: endothelin-1 from 0.63±0.09 fmol/ml to 0.23±0.03 (p=0.002), PAI-1 from 5.69±0.24 to 3.06±0.25 U/ml (p<0.001); elevated level of t-PA from 5.03±0.3 to 5.64±0.3 ng/ml. CONCLUSION.The spironolactone therapy in program hemodialysis patients results in lower level of aldosterone in blood and better state of the endothelial function.
About the Authors
A. Zh. Karabaeva
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова;
городская клиническая больница № 15, Санкт-Петербург
Russian Federation
Russian Federation
A. M. Essaian
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова;
городская клиническая больница № 15, Санкт-Петербург
Russian Federation
Russian Federation
I. G. Kayukov
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова;
городская клиническая больница № 15, Санкт-Петербург
Russian Federation
Russian Federation
M. M. Timofeev
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова;
городская клиническая больница № 15, Санкт-Петербург
Russian Federation
Russian Federation
O. V. Volkova
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова;
городская клиническая больница № 15, Санкт-Петербург
Russian Federation
Russian Federation
A. D. Khristenko
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова;
городская клиническая больница № 15, Санкт-Петербург
Russian Federation
Russian Federation
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Review
For citations:
Karabaeva A.Zh., Essaian A.M., Kayukov I.G., Timofeev M.M., Volkova O.V., Khristenko A.D. THE INFLUENCE OF SPIRONOLACTONE THERAPY ON THE LEVEL OF ALDOSTERONE AND DYSFUNCTION OF THE ENDOTHELIUM IN PROGRAMMED HEMODIALYSIS PATIENTS. Nephrology (Saint-Petersburg). 2007;11(2):55-58. (In Russ.) https://doi.org/10.24884/1561-6274-2007-11-2-55-58
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