EFFECTS OF OSMOTIC LOADS ON THE FUNCTIONAL STATE OF THE KIDNEYS IN HEALTHY VOLUNTEERS

Abstract

THE AIM of the investigation was to study activity of the kidneys in healthy subjects under conditions of different value concentrations of sodium chloride of watersalt loads in order to elucidate the character and mechanisms of their effects and to analyze how suitable this method is for clinical and experimental medicine. PATIENTS AND METHODS. The method of investigation of the renal functional reserve (RFR) was tested in healthy subjects using the sodium chloride solution in concentrations from 0.05 to 0.5%, volume 0.5% of the body mass. RESULTS. It was found that loading with 0.5% sodium chloride solution as compared with the water load is followed by a reliably increased excretion of creatinine, nitrites and osmotically active substances, as well as increased osmolality of urine. CONCLUSION. The results obtained allow a conclusion that when loaded with 0.5% sodium chloride solution the excretion of osmotic load is due to increased filtration charge, the watersalt load with the concentration of sodium chloride equal to 0.5% with the volume of 0.5% of the body mass inducing the involvement of RFR as compared with the reaction to water load.