MORPHOLOGICAL ALTERATIONS IN THE KIDNEYS IN GOUTY GLOMERULONEPHRITIS

Abstract

THE AIM of the work was to analyze morphological alterations in the kidneys in gouty glomerulonephritis using investigations of bioptates of living patients and sectional findings. PATIENTS AND METHODS. There were 28 histological examinations of the renal tissue, nephrobiopsy was performed in 21 of the patients (1st group). In 7 cases the sectional material was studied taken from corpses of people dead from renal failure (2nd group). Morphological alterations in the renal tissue in gouty glomerulonephritis were assessed. RESULTS. It was found that the alterations in the kidneys of the first group patients corresponded to focal mesangial proliferative (62%) and mesangiocapillary glomerulonephritis (28.6%). Both morphological forms of glomerulonephritis are accompanied by a sharply pronounced tubulointerstitial component. Alterations in the kidneys of the second group reflected nephroangiosclerotic processes. The degree of the alterations in the renal tissue depended on the duration of the disease. CONCLUSION. The data obtained suggest the presence of different variants of glomerular lesions of the kidneys with a sharply pronounced tubulointerstitial components in patients with gout.