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ROLE OF MODIFIABLE FACTORS IN THE DEVELOPMENT OF DIFFICULT TO CORRECT ARTERIAL HYPERTENSION IN CHRONIC RENAL FAILURE

https://doi.org/10.24884/1561-6274-2004-8-3-42-47

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Abstract

THE AIM of the investigation was to assess the role of modifiable factors in the development of stability of arterial hypertension (AH) in relation to hypotensive therapy as a whole and to therapy with loop diuretics in patients with chronic renal failure (CRF). PATIENTS AND METHODS. Under examination there were 103 patients with CRF and secondary AH. In 42 patients AH could be easily corrected by standard hypotensive therapy. In 61 patients AH failed to be corrected, so in order to normalize arterial pressure these patients received injections of furosemid in dose of 80 mg (120 mg at GFR<30 ml/min) in addition to their treatment. In these patients an assessment was made of the influence on the development of AH of such factors as age, gender, character of therapy received by the patients from the moment of diagnosis of the disease, keeping the regimen of treatment by the patient. RESULTS. Patients limiting consumption of salt could more easily reach normal arterial pressure both against the background of usual hypotensive therapy (χ2= 10.38; p<0.001) and under effects of furosemid (χ2=9.35; p<0.004), than patients taking salt ad libitum. Excessive consumption of water also facilitated the development of stable AH (χ2 =5.86; p<0.02). Indirect findings were obtained concerning the ability of the angiotensinconverting enzyme inhibitors to prevent the development of stable AH. Inconstant taking of hypotensive drugs facilitated the formation of stable hypertension (χ2 =5.19; p<0.02). CONCLUSION. The development of difficult to correct AH in pathology of the kidneys depends on many external modifiable factors that proves the significant role of the patients and doctors in prevention of progression of AH.

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Fetisova N.V., Lukichev B.G. ROLE OF MODIFIABLE FACTORS IN THE DEVELOPMENT OF DIFFICULT TO CORRECT ARTERIAL HYPERTENSION IN CHRONIC RENAL FAILURE. Nephrology (Saint-Petersburg). 2004;8(3):42-47. (In Russ.) https://doi.org/10.24884/1561-6274-2004-8-3-42-47

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)