CORRELATION OF UREMIC TOXINS AND INFLAMMATION MARKERS IN PATIENTS WITH CHRONIC RENAL FAILURE

THE AIM of the work was to study effects of substances of low and middle molecular mass (SLMMM), considered as uremic toxins, upon the indicators showing inflammation. PATIENTS AND METHODS. The investigated group included 30 patients with normal function of the kidneys, 77 patients with predialysis stage of chronic renal failure (CRF) and 54 patients with terminal CRF receiving substitution therapy with hemodialysis (HD). At the moment of examination the patients did not have symptoms of exacerbation of the main disease of the kidneys or coexisting diseases. The concentration of SLMMM was determined in patients with different stages of CGN and then a correlation analysis of interrelations between SLMMM and indices of inflammation (ESR, fibrinogen, CRP, IL6, TNFalpha, albumin, albumin binding power) was made. RESULTS. Positive correlative interrelations of SLMMM with ESR, fibrinogen, IL6 and negative with albumin and albumin binding power were obtained. When the SLMMM indices were elevated the indices of general inflammatory syndrome became worse: ESR, level of IL6 and fibrinogen became higher, while albumin and albumin binding power decreased. CONCLUSION. An analysis of the data obtained allows a supposition that uremia is a cause maintaining inflammation in patients with CGN and in future can result in the development of atherosclerosis, ischemic heart disease, complications to the cardiovascular system.

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