MORPHOLOGICAL RISK FACTORS OF LOCAL RECURRENCE AFTER RADICAL PROSTATECTOMY
https://doi.org/10.24884/1561-6274-2004-8-4-89-91
Abstract
THE AIM of the investigation was to find out morphological risk factors and to make a mathematical prognostic model of a local recurrence of tumor in patients with prostate cancer after radical prostatectomy. PATIENTS AND METHODS. An analysis of incidence of local recurrences of tumor in 150 patients with localized forms of prostate cancer after radical retropubic prostatectomy was made with special reference to the results of morphological investigation. RESULTS. A local recurrence of tumor after radical prostatectomy took place in 13 (8.7%) patients. The leading morphological risk factors of its appearance (the greatest coefficient of factor load, F) were: positive surgical edge (F=54,20, growth of tumor into the seminal vesicles (F=31.56%) and metastases in the regional lymph nodes (F=21.14). A mathematical model allowing prognosis of its appearance with 84.6% probability was made on the basis of the analysis of morphological factors of risk of recurrence of prostate cancer. CONCLUSION. The assessment of probability of the appearance of local recurrence of tumor is necessary for planning the treatment of the patients after radical prostatectomy with special reference to morphological risk factors.
About the Authors
S. Yu. Borovets
Санкт-Петербургский государственный медицинский университет им.акад. И.П. Павлова
Russian Federation
Russian Federation
V. V. Kozlov
Санкт-Петербургский государственный медицинский университет им.акад. И.П. Павлова
Russian Federation
Russian Federation
References
1. Аль-Шукри СХ, Ткачук ВН. Опухоли мочеполовых органов: руководство для врачей. «Питер», СПб, 2000; 278 – 279
2. Lepor H. Practical consideration in radical retropubic prostatectomy. Urol Clin North Am 2003; 30(2):363368
3. Downs TM, Kane CJ, Grossfeld GD et al. Surgery for prostate cancer: rationale, technique and outcomes. Cancer Metastasis Rev 2002; 21 (1): 29 44
4. Swanson GP, Riggs MW, Earle JD, Haddock MG. Longterm followup of retropubic prostatectomy for prostate cancer. Eur Urol 2002; 42(3): 212 – 216
5. Horiguchi A, Nakashima J, Horiguchi Y et al. Prediction of extraprostatic cancer by prostate specific antigen density, endorectal MRI, and biopsy Gleason score in clinically localized prostate canser. Prostate 2003; 56(1): 2329
6. RiouxLeclercq NC, Chan DY, Epstein JI. Prediction of outcome after radical prostatectomy in men with organconfined Gleason score 8 to 10 adenocarcinoma. Urology 2002; 60 (4): 666 – 669
7. Grossfeld GD, Latini DM, Lubeck DP et al. Predicting recurrence after radical prostatectomy for patients with high risk prostate cancer. J Urol 2003; 169 (1): 157 – 163
8. Palisaan RJ, Graefen M, Karakiewicz PI et al. Assessment of clinical and pathologic characteristics predisposing to disease rercurence following radical prostatectomy in men with pathologically organconfined prostate cancer. Eur Urol 2002; 41(2): 155 – 161
9. Freedland SJ, Csathy GS, Dorey F, Aronson WJ. Percent of prostate needle biopsy scores with cancer is significant independent predictor of prostate specific recurrence following radical prostatectomy: results from search database. J Urol 2003; 169 (6): 2136 – 2141
10. Поллаpд Дж. Спpавочник по вычислительным методам статистики. Пеp. с англ. – Финансы и статистика, М., 1982; 344
Review
For citations:
Borovets S.Yu., Kozlov V.V. MORPHOLOGICAL RISK FACTORS OF LOCAL RECURRENCE AFTER RADICAL PROSTATECTOMY. Nephrology (Saint-Petersburg). 2004;8(4):89-91. (In Russ.) https://doi.org/10.24884/1561-6274-2004-8-4-89-91
Views:
316
Email this article 