WATER DEPRIVATION INFLUENCES THE EXTRANEURONAL MEDIATOR POOL OF WHITE RAT’S KIDNEYS AND RENAL POPULATION OF MAST CELLS
https://doi.org/10.24884/1561-6274-2003-7-2-76-81
Abstract
THE AIM of the work was to investigate the bioamine status of the kidney. MATERIAL AND METHODS. Two series of experiments were carried out. The first series included 10 white rats: 4 - controls, 3 - one day of water deprivation (WD), 3 - two days of WD with free access to dry food. RESULTS. During the first day WD decreased the intensity of fluorescence of catecolamines (CA), serotonin (S) and histamine (H) 2-3 times (p< 0.01) in all parts of the nephron.On the second day of WD there was a tendency to restore the initial level of CA and S, but the fluorescence remained reliably lower than in control, the fluorescence of H was completely restored. Fluorescence of acetylcholine (ACH) during the first days of WD was 7-8 times greater in the glomeruli and Henle’s loops, and 2-3 times in the tubules (p<0.001). In all parts of the nephron there was a strong negative correlation between ACH and other mediators under study (p<0.01) and strong and median positive correlation between other mediators. In the second series having the same scheme the influence of WD on the renal population of mast cells (MC) was investigated. Beginning from the first day WD resulted in 2 times greater number of MC in the subcapsular zone of the kidneys which remained high. In the medullary zone the number of MC was 8 times greater on the second day. CONCLUSION. The extraneuronal pools of renal CA, S, H 1ACH and MC are involved in the regulation of the renal status in WD.
About the Authors
V. A. Kozlov
Чувашский государственный университет им. И.Н. Ульянова
Russian Federation
Russian Federation
O. S. Glazyrina
Чувашский государственный университет им. И.Н. Ульянова
Russian Federation
Russian Federation
A. Yu. Tolmacheva
Чувашский государственный университет им. И.Н. Ульянова
Russian Federation
Russian Federation
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For citations:
Kozlov V.A., Glazyrina O.S., Tolmacheva A.Yu. WATER DEPRIVATION INFLUENCES THE EXTRANEURONAL MEDIATOR POOL OF WHITE RAT’S KIDNEYS AND RENAL POPULATION OF MAST CELLS. Nephrology (Saint-Petersburg). 2003;7(2):76-81. (In Russ.) https://doi.org/10.24884/1561-6274-2003-7-2-76-81
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