EFFECTS OF GLUTARGINE AND ARGININE ON THE COURSE OF IFOSFAMIDE INDUCED EXPERIMENTAL RENAL FAILURE IN WHITE RATS
https://doi.org/10.24884/1561-6274-2007-11-3-82-85
Abstract
THE AIM of the investigation was to study in experiments the nephroprotective effect of arginine and glutargine in rats receiving cytostatic ifosfamide. MATERIALS AND METHODS. The nephrotoxic effects of ifosfamide were studied in white rats under conditions of 5% water diuresis in 7 days after daily administration of the cytostatic (5 mg/100 g b.m). Protective effects of arginine or glutargine were studied under conditions of water diuresis after the 7-day combined administration of ifosfamide and one of the substances. RESULTS. It was found that administration of ifosfamide to white rats during 7 days caused a moderate decrease of glomerular filtration rate and the values of standardized per 1 ml of the glomerular filtrate of excretion of osmotically active substances and proteins. In its turn, a combined administration to the animals of glutargine and arginine contributes tore-establishment of the glomerular filtration rate and normalization of transport of osmotically active substances and proteins. CONCLUSION. The nephrotoxic effects of glutargine and arginine are realized at the channel and glomerule level, and glutargine and arginine decrease the degree of kidney lesion.
About the Authors
A. I. Gozhenko
Научно-исследовательский институт медицины транспорта, г. Одесса
Ukraine
Ukraine
M. V. Trusova
Научно-исследовательский институт медицины транспорта, г. Одесса
Ukraine
Ukraine
References
1. Rossi R, Godde A, Kleinebrand A et al. Concentrating capacity in ifosfamide-induced severe renal dysfunction. Ren Fail 1995; 17(5): 551-557
2. Berns JS, Haghighat A, Staddon A et al. Severe, irreversible renal failure after ifosfamide treatment. A clinicopathologic report of two patients. Cancer 1995; 76 (3): 497-500
3. Prasad VK, Lewis IJ, Aparicio SR et al. Progressive glomerular toxicity of ifosfamide in children. Med Pediatr Oncol 1996; 27(3): 149-155
4. Bokemeyer C, Fels LM, Dunn T et al. Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin or ifosfamide anti-tumour activity. Br J Cancer 1996; 74(12): 2036-2041
5. Nissim I, Weinberg JM. Glycine attenuates Fanconi syndrome induced by maleate or ifosfamide in rats. Kidney Int 1996; 49(3): 684-695
6. Foxall PJ, Lenz EM, Lindon JC et al. Nuclear magnetic resonance and high-performance liquid chromatography-nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide. Ther Drug Monit 1996; 18(4): 498-505
7. Возіанов ОФ, Гоженко АІ, Федорук ОС. Гостра ниркова недостатність. Одеський медичний університет, Одесса, 2003; 375
8. Меркулова ЮВ, Гомон ОН, Чайка ЛА. Глутаргін – нові принципи фармакотерапії захворювань печінки: Зб. наук. праць наук.-практ. конф. Харків, 2003: 7-9
9. Берхин ЕБ, Иванов ЮИ. Методы экспериментального исследования почек и водно-солевого обмена. Алтайское кн. Изд., Барнаул, 1972; 199
10. Рябов СИ, Наточин ЮВ, Бондаренко ББ. Диагностика болезней почек. Медицина, Л., 1979; 256
11. Михеева АИ, Богодарова ИА. К методике определения общего белка в моче на ФЭК-Н-56. Лаб дело 1969; (7): 441-442
12. Stuben J, Port R, Bertram B et al. Pharmacokinetics and whole-body distribution of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard and its effects on the incorporation of [methyl-3H]-thymidine in various tissues of the rat. Cancer Chemother Pharmacol 1996; 38(4): 355-365
13. Гоженко АИ. Энергетическое обеспечение основных почечных функций и процессов в норме и при повреждении почек. Дис… д-ра мед. наук. Черновцы, 1987; 368
14. Пішак ВП, Гоженко АІ, Роговий ЮЄ. Тубуло-інтерстиціальний синдром.: Медакадемія, Чернівці, 2002; 221
15. Lopau K, Kleinert D, Erler J et al. Tacrolimus in acute renal failure: does L-arginine-infusion prevent changes in renal hemodynamics? Transpl Int 2000; 13 (6): 436-442
16. Higashi Y, Oshima T, Ono N et al. Intravenous administration of L-arginine inhibits angiotensin-converting enzyme in humans. J Clin Endocrinol Metab 1995; 80(7): 2198-2202
Review
For citations:
Gozhenko A.I., Trusova M.V. EFFECTS OF GLUTARGINE AND ARGININE ON THE COURSE OF IFOSFAMIDE INDUCED EXPERIMENTAL RENAL FAILURE IN WHITE RATS. Nephrology (Saint-Petersburg). 2007;11(3):82-85. (In Russ.) https://doi.org/10.24884/1561-6274-2007-11-3-82-85
Views:
354
Email this article 