LEFT VENTRICLE MYOCARDIUM DYSFUNCTION IN CHRONIC GLOMERULONEPHRITIS PATIENTS AND MAIN APPROACHES TO ITS CORRECTION

Abstract

THE AIM of the investigation was to develop pathogenetical approaches to correction of the myocardial dysfunction in chronic glomerulonephritis patients with the preserved function of the kidneys. PATIENTSAND METHODS. The examination of 43 patients with chronic glomerulonephritis included 5 women and 38 men. The mean age of the patients was 35.6± 2.35 years, duration of the diseasewas7.8±0.5years. Nephrotic syndrome was observed in 7 (16.3%) patients, urinal syndrome - in 36 (83.7%) patients, 7 (16.3%) patients had mesangial proliferative glomerulopnephritis established by nephrobiopsy, 3 (6.9%) patients had mesangiocapillary glomerulonephritis and 15 (34.8%) patients had arterial hypertension. RESULTS. Symptoms of the left ventricle myocardium dysfunction were revealed in 34 patients (76.1%), systolic in 13.9% out of them, diastolic - in 65.2%. Administration of beta-adrenoblockers is expedient in patients with the development mainly of diastolic dysfunction of the left ventricle myocardium, and with the systolic dysfunction - the angiotensine converting enzyme inhibitors. CONCLUSION. The differentiated approach to the correction of contractile disorders of the myocardium is a pathogenetically substantiated method of treatment of heart failure in patients with chronic glomerulonephritis.