CHANGES IN THE LEVELS OF INTERLEUKINS 6 AND 10 AND WATER-SALT HOMEOSTASIS IN THE DEVELOPMENT OF POST-LOADING PROTEINURIA

Abstract

THEAIM of the work was to elucidate the possible role of changes in the levels of IL 6 and 10 and certain indices of water-salt homeostasis in the appearance of post-loading proteinuria (PLP) in miners working in deep coal mines. PATIENTSAND METHODS. The investigation was performed on 72 workers in a deep mine after a preliminary medical examination. The examined were divided into 2 groups: I - subjects without proteinuria after shift, Il - subjects with symptoms of proteinuria (albumin from 0.1 to 0.2 g/l) after shift. Control group consisted of 20 practically healthy subjects not engaged in underground workings. Contentof electrolytes (K ⁺, Cl ^-, Na ⁺) in blood and urine was determined by the method of flame photometry by a conventional technique. The level of creatinine in blood and urine was determined by the Popper method. The glomerular filtration rate (GFR) was calculated by the endogenous creatinine clearance using the Cocroft-Gault formula. Concentration of IL 6 and 10 in blood plasma was investigated by ELISA immunoenzyme analysis. RESULTS. The investigations performed in the group of miners with post-loading proteinuria have revealed appreciably changed indices of water-salt homeostasis and levels of IL 6 and I0 which were aggravated during the shift. CONCLUSION. The intensified interaction between different components of water-salt homeostasis and expression of IL in subjects with PLP testifies to a considerable strain of the body mechanisms responsible for maintaining homeostasis.