SPECIFIC FEATURES OF ION-REGULATING FUNCTION OF THE KIDNEYS OF EXPERIMENTAL ANIMALS IN PERFORMING POTASSIUM LOAD TESTS PREPARED WITH TAP WATER AND DISTILLED WATER

Abstract

THE AIM of the investigation was to study homeostatic reactions of the kidneys on administration of solutions of potassium chloride prepared with tap water and distilled water. MATERIAL AND METHODS. Intragastric infusions of 0.45% solutions of potassium chloride in 3% volume of body mass were made through a probe to white outbred rats. Total diuresis was registered for 2 hours and the concentration of sodium, potassium, magnesium, titrated acids and ammonia were determined. Excretion of the substances under study was calculated totally for 2 hours in recalculation on 100 g of body mass of the animal. RESULTS. It was found that excretion of potassium by the kidneys was reliably higher in the animals which were given solutions of potassium chloride prepared with distilled water, with the absence of reliable changes of diuresis, excretion of sodium, potassium, magnesium, titrated acids and ammonia. CONCLUSION. It is supposed that the differences in reactions of the white rat kidneys are associated with specific physical structure of tap water and distilled water.