Preview

Nephrology (Saint-Petersburg)

Advanced search

GLYCATED HEMOGLOBIN IN DIABETIC NEPHROPATHY PATIENTS

https://doi.org/10.24884/1561-6274-2003-7-1-76-79

Abstract

The aim of the work was to determine the relationship of glycated hemoglobin (GH) and diabetic nephropathy (DN). We investigated 20 patients with diabetes mellitus (DM) and used the method of thiobarbituric colorimetry with preliminary isoelectrofocusing of HbA1 с for the determination of GN. AU the patients with DM had an inadequate level or high vascular risk of glucose control. In 14 patients there was microalbuminuria (0.03-0.39 g/l), 4 patients had DH with proteinuria (>0.3 g/l) and 2 patients had chronic renal insufficiency. AU the patients did not have linear correlation but had a parabolic dependence between GH level and proteinuria (y=-0.5667+0.1621 x-0.0065 X 2). The regression error D=3.4303.

About the Authors

V. A. Korolev
Крымский государственный медицинский университет им. С.И. Георгиевского
Ukraine


O. V. Glushkova
Крымский государственный медицинский университет им. С.И. Георгиевского
Ukraine


G. I. Gordeeva
Крымский государственный медицинский университет им. С.И. Георгиевского
Ukraine


References

1. Гордеева Г.И., Королев В.А. Контроль диабетической нефропатии//Нефрологический семинар,2001.-Сб.научн.тр. СПб нефрологического семинара, 18-21 июня 2001, Спб, ТНА,2001-с.123-124.

2. Дедов И.И., Шестакова М.В. Диабетическая нефропатия. -М.: «Универсум Паблишинг», 2000.

3. Добронравов В.А. Диабетическая нефропатия: эпидемиология, диагностика, течение, особенности почечных функций, прогноз, подходы к терапии,-Автореф. дис.. д-ра мед.наук.-СПб,2000.-35с.

4. Королев В.А., Головская, Белокуренко В.П. и др. Оценка колориметрического метода определения гемоглобина Al с//Клин.лаб.диагн.-2001.-№12.-С.12-14.

5. Лабораторные методы исследования в клинике: Справочник/Меньшиков В.В., Делекторская Л.H., Золотницкая Р.П. и др.; Под ред. В.В.Меньшикова-М.:Медицина, 1987,-368с.

6. Раков А.П. Роль различных вариантов нарушений углеводного обмена и тканевой инсулинорезистентности в формировании сердечно-сосудистой патологии. Дис.. д-ра мед.наук.-СПб,1990.

7. Шестакова М.В. Диабетическая нефропатия: итоги XX века, перспективы XXI века//Сахарный диабет.-2000-N.I -С.15-18.

8. Agardh CD., Agardh E., Torffvit О. The association between retinopathy, nephropathy, cardiovascular disease and long-term metabolic control in type 1 diabetes mellitus: a 5 year follow-up study of 442 adult patients in routine care//Diab. Res. Clin. Pract.-Vol.35.-N.2-3.-P.113-121.

9. Anonymous. Risk factors for development of microalbuminuria in insulin dependent diabetic patients: a cohort study. Microalbuminuria Collaborative Study//Brit.Med.J.-1993.-Vol. 306 (6887).-P.1235-1239.

10. Bojestig M., Arnqvist H.J., Karlberg B.E., Ludvigsson J. Glycemic control and prognosis in type I diabetic patients with microalbuminuria//Diabetes Care-1996.-Vol. 19.-N.4.-P.313-317.

11. BrunoG., Cavallo-Perin P., Bargero G. et al. Prevalence and risk factors for micro-and macroalbuminuria in an Italian population-based cohort of NiDDM subjects//Diabetes Care.-1996.-Voi.19, N.1.-P.43-47.

12. Gebre-Yohannes A., Rahlenbeck S.I. Glycaemic control and its determinants in diabetic patients in Ethiopia//Diab. Res. Clin Pract.-1997.-Vol.35, N.2-3.-P.129-134.

13. Gonzalez-Clemente J.M., Esmatjes E., Navarro P.et al. Microalbuminuria development in short-term IDDM//Diab.Res. Clin. Pnact.-1994.-Vol.24, N.1.-P.15-23.

14. Guidelines for Diabetes Care. A desktop guide to type

15. diabetes mellitus. European Diabetes Policy Group. 1998-1999.

16. Guidelines for Diabetes Care. A Deskto Guide to Type 1 Diabetes Mellitus. EDPG11998.

17. Hsu C.Y., Bates D.W., Kuperman G.J. et al. Diabetes, hemoglobin A(1 с), cholesterol, and the risk of moderate chronic renal insufficiency in an ambulatory population//Am.J.Kidney Dis.-2000.-Vol.36, N 2.-P.272-281.

18. Kohler S.M., Kramer B.K. Current therapeutic management of diabetic nephropathy//Acta Diabetologica.-1994.-Vol.31, N 3.-P.119-125.

19. Krolewski A.S., Laffel L.M., Krolewski M. et al. Glycosylated hemoglobin and the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus//New Engl. J. Med.-1995.-Vol.332, N 19.-P.1251-1255.

20. Morgan L., Marenah C.B., Jeffcoate W.J., Morgan A.G. Glycated proteins as indices of glycaemic control in diabetic patients with chronic renal failure//Diab. Med.-1996.-Vol.13, N6.-P.514-519.

21. Prendergast C., Smyth O., Murray F. et al. The relationship of blood glucose and haemoglobin Al levels in diabetic subjects//lr. J. Med. Sc.-1994.-Vol.163, N 5.-P.233-235.

22. Takahashi Y., Noda M., Tsugane S. et al. Prevalence of diabetes estimated by plasma glucose criteria combined with standardized measurement of HbAIc among health checkup participants on Miyako Island, Japan//Diabetes, Care.-2000,-Vol.23, N 8.-P.1092-1096.

23. World Health Organization Definition and Classification of Diabetes Mellitus and its Complications. Part 1. Diagnosis and Classification of Diabetes Mellitus. Geneva11999.-59p.


Review

For citations:


Korolev V.A., Glushkova O.V., Gordeeva G.I. GLYCATED HEMOGLOBIN IN DIABETIC NEPHROPATHY PATIENTS. Nephrology (Saint-Petersburg). 2003;7(1):76-79. (In Russ.) https://doi.org/10.24884/1561-6274-2003-7-1-76-79

Views: 445


ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)