EFFECTS OF ARGININE, PREDUCTAL AND SORBILACT ON RENAL FUNCTION OF RATS WITH SUBLIMATE NEPHROPATHY

Abstract

The aim of the work was to follow the effectiveness of arginine for correction of acute renal insufficiency (ARI) at sublimate nephropathy and to determine the optimum combinations with other medicines. Experiments were carried out in 51 white male Wistar rats. The animals were kept on a low sodium diet (sodium content up to 50 mkmol/day). The function of the kidneys was investigated in rats of a control group and four groups of animals with AR) caused by subcutaneous injection of corrosive sublimate (5 mg/kg of body mass in isotonic solution) in 24 hours after injection (oliguria period) under conditions of water diuresis. Corrosive sublimate, arginine chloride, arginine and preductal were injected to the 4 groups of rats intraperitoneally (5 mg/kg); arginine chloride and hyperosmolar infusion solution sorbilact. It was shown that the proposed approach is perspective for treatment of kidneys affected by sublimate and most likely of all other toxic nephropathies since it is pathogenetically substantiated. Choice of the medicine possessing a vasodilatation effect - arginine or sorbilact - mainly depends on the character of disorders of the water-salt metabolism and hemodynamics.