Urinary infection: the morphological changes in renal parenchyma in rats (experimental investigation)
Abstract
AIM OF RESEARCH: To study in chronic experiments on rats pathomorphological changes in kidney in urinary tract infection. MATERIALS AND METHODS: In experimental on rats used pyelonephritis modeling method, which reproduced by introducing daily culture E. Coli in the amount 200-500 mln. microbic bodies into ureter lumen, with its subsequent ligation. RESULTS: It is established that in all observation time after simulated pathological processes considerable morphological changes mainly occurred in the kidneys tubules and interstitial. The changes presented with signs of infiltrative-productive inflammation as well as fibrosis of different levels of intensity. CONCLUSION: A definite correlation between the type of simulated pathological process and the intensity of morphological changes in the kidneys was revealed. Microscopic changes can serve as criteria of kidneys parenchyma involvement in the pathological process as well as to become an important prognostic sign.
About the Authors
N. M. Zaikova
Institution of Mother and Child Care
Russian Federation
Russian Federation
V. G. Petrovich
Institution of Mother and Child Care
Russian Federation
Russian Federation
L. V. Sinitsina
Institution of Mother and Child Care
Russian Federation
Russian Federation
V. V. Dlin
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
A. A. Korsunskii
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
P. M. Stratulat
Institution of Mother and Child Care
Russian Federation
Russian Federation
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Review
For citations:
Zaikova N.M., Petrovich V.G., Sinitsina L.V., Dlin V.V., Korsunskii A.A., Stratulat P.M. Urinary infection: the morphological changes in renal parenchyma in rats (experimental investigation). Nephrology (Saint-Petersburg). 2015;19(3):72-78. (In Russ.)
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