THE INFLUENCE OF OMAKOR ON THE INDICES OF LIPID METABOLISM IN CHILDREN HAVING GLOMERULONEPHRITIS WITH NEPHRITIC SYNDROME

Abstract

THE AIM of the work was to assess effects of Omakor on the indices of lipid metabolism in children having glomerulonephritis with nephritic form (NF) of chronic glomerulonephritis (CGN). PATIENTS AND METHODS. Examinations were performed on 62 sick children (34 boys and 28 girls) with NF CGN, mean age 11,6±0, 17 years, prescription of the disease 4,31±0,31 years.In 13 children there were impaired functions of the kidneys. In the first group 38 children were given standard therapy; 24 children of the second group were given Omakor 1 capsule a day (in the morning after meal) during 15 days against the background of standard therapy. Indicators of the lipid specter were estimated with a biochemical autoanalyzer «Daytona» from Randox. RESULTS. Inclusion of Omakor in the complex of standard therapy resulted in a reliable decrease of total cholecterol (TCS) in children with the savedand impaired function of kidneys as compared with the initial values the1.2 and 1.4 times respectively, triglyceride (TG) – 1.24 and 1.23 times, cholesterol of lipoproteins of low density (CS-LPLD) – 1.32 and 1.64 times. The level of cholesterol of very low density lipoproteins (CS VLDL) had a tendency to decrease, cholesterole of high density lipoproteins (CS HDL) to increase. Such alterations in the patients’ l.ipid specter of blood serum promoted decreased coefficient of atherogenicity to 3.26± 0.15 and 3.29±0.83. CONCLUSION. Standard therapyNF CGN fails to substantially influence on dyslipoproteidemia. Inclusion of Omakor in the standard therapy promoted a reliably decreased levels of TG, TCS, CS -VLDL and CS –HDL, and as a consequence, atherogeneity coefficient.