THE PROGNOSTIC ROLE OF TUMOR ANGIOGENESIS IN THE COURSE OF TRANSITIONAL CELL CANCER OF URINARY BLADDER

Abstract

THE AIM of the study to investigate the special features of angiogenesis of transitional cell cancer of urinary bladder and correlate them with clinical data, degree of differentiation and deep invasion of the tumor. PATIENTS AND METHODS. The retrospective analysis of clinically investigated 16 patients with transitional-cellular tumor of urinary bladder was conducted. The vessels of the tumor tissues were colored by means of immunohistochemical method with the use of CD34 antibodies. RESULTS. The depth of the invasion of the tumor Tis, Ta, T1, T2, T3, T4 and TX was detected in 1 (6 %), 2 (13 %), 1 (6 %), 2 (13 %), (13%), 2 (13 %) cases accordingly, and the stage of the differentiation G1, G2 and G3 – in 6 (36 %), 6 (36 %) and 4 (28 %) cases accordingly. With the lower stage of the differentiation of transitional cell carcinoma the amount of micro-vessels in the tumor tissues increased (r=0,68; p=0,04; rs=0,56; p=0,023; H=6,55; p=0,038; F=9,41; p=0,003). Tumors with moderate and low stage of the differentiation were reliably different by the density of micro-vessels (t=2,94; p=0,019). The comparative study of tumor tissue with the stages of differentiation G1 and G2 showed that they differ in the number of micro-vessels in the observation field inthe greatest extent (t=4,34; p=0,02; U=0,00; p=0,011). CONCLUSION. The conducted investigation allows to make the conclusion that the determination of the angiogenic activity of carcinoma of the urinary bladder can be a valuable factor for prognosis of the disease course. The determination of the intensity of the blood flow of the tumor allows us to suppose that it is closely connected with the differentiation stage of the transitional cell carcinoma and could be recommended as a clinic-morphological criteria, supplementing the current classification of the transitional-cellular tumor of urinary bladder.