THE STATE OF ANTIOXIDANT BLOOD POTENTIAL AND FREE RADICAL LIPID OXIDATION IN ALCOHOLIC PATIENTS, WITH RENAL DAMAGE

Abstract

THE AIM. To investigate the activity of free radical processes in alcoholic patients (A), associated with renal damage (A with RD), and the role of depression of effectiveness of regulatory mechanisms, restricting the accumulation of high toxicity products of free radical lipid oxidation (FrLO), in the formation of the nephropathy in these patients. PATIENTS AND METHODS. Were evaluated 57 male patients (mean age of 31 ± 2,8 years), suffering from A during 5-10 years and admitted to the hospital in the state of urgent alcohol abstinence. The renal damage was discovered in 17 (29,8 %) patients. The control group included 20 healthy patients. The activity of FrLO and antioxidant defense was studied. RESULTS. In patients A the values of studied features, showing the activity of FrLO, were statistically higher than those in the healthy group patients. In these patients was discovered the depression of the first and second line mechanisms of AOD. Showed deviation was more obvious in the group of patients A with RD. CONCLUSION. The activation of FrLO developing on the phone of AOD depression, probably, played a role in the development of nephropathy in A patients.