Vascular adhesive protein-1 (VAP-1) and its role in modeling of inflammation and fibrosis. Nephrology vector
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Abstract
There is the whole proteins family, localized on cellular surfaces and regulating lymphocyte-endoteliocyte interaction process, called ekto-peptides. VAP-1 (vascular adhesive protein-1) also belongs to it. Human VAP-1 is the dimeric membrane protein with molecular weight of 180 kD consisting of short N-trailer cytoplasmatic tail, transmembrane domain and most extracellular part. VAP-1 stimulates lymphocytes rolling, adhesion and transmigration through endothelial vessels lining, and also polymorphic and nuclear leukocytes. During studying of VAP-1 expression in kidneys, it is found in peritubular capillaries and perithelial cells of the, and also in smooth muscle cells of larger vessels. Almost completely absent is VAP-1 expression in glomerular endothelial cells.Further studying of signal VAP-1-mediated pathway influence on glomerulonephritis course and outcomes will provide to expand ideas of disease pathogenesis and new influence ways on chronic kidney disease progressing.
About the Authors
M. M. Batiushin
Rostov State Medical University
Russian Federation
Russian Federation
H. Z. Gadaborsheva
Rostov State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Batiushin M.M., Gadaborsheva H.Z. Vascular adhesive protein-1 (VAP-1) and its role in modeling of inflammation and fibrosis. Nephrology vector. Nephrology (Saint-Petersburg). 2015;19(5):23-27. (In Russ.)
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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)
ISSN 2541-9439 (Online)
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