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Интерес к изучению роли желудочно-кишечного тракта в поддержании гомеостаза при хронической болезни почек является традиционным. Он послужил, в частности, отправной точкой для создания энтеросорбентов. Однако, если ранее основное внимание было обращено на механическое удаление ряда потенциально опасных биологически активных веществ, то в последнее время предметом интереса стала кишечная микробиота. Возрос интерес к коррекции дисбиоза с целью снижения уровня уремических токсинов, активности окислительного и воспалительного стресса. Вторая часть обзора литературы на эту тему посвящена вопросам применения пребиотиков, пробиотиков и синбиотиков.Подробно изложены современные трактовки терминов. Дана классификация средств, используемых при хронической болезни почек. Представлены потенциальные механизмы их действия. Обсуждены позитивные и негативные результаты экспериментальных и клинических исследований.
Проф. Лукичев Борис Георгиевич, д-р мед. наук
197022, Санкт-Петербург, ул. Л. Толстого, д. 17. Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, кафедра пропедевтики внутренних болезней. Тел.: (812)-234-01-65
Проф. Румянцев Александр Шаликович, д-р мед. наук
199106, Санкт-Петербург, 21-я линия В.О., д. 8а. Санкт-Петербургский государственный университет, кафедра факультетской терапии. Тел.: +7 (812) 326-03-26
Проф. Панина Ирина Юревна, д-р мед наук
197022, Санкт-Петербург, ул. Л. Толстого, д. 17. Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, кафедра пропедевтики внутренних болезней. Тел.: (812)-234-01-65
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Лукичев Б.Г., Румянцев A.Ш., Панина И.Ю., Акименко В. МИКРОБИОТА КИШЕЧНИКА И ХРОНИЧЕСКАЯ БОЛЕЗНЬ ПОЧЕК. СООБЩЕНИЕ ВТОРОЕ. Нефрология. 2019;23(1):18-31. https://doi.org/10.24884/1561-6274-2018-23-1-18-31
Lukichev B.G., Rumyantsev A.S., Panina I.Y., Akimenko V. COLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASES INTESTINAL MICROBIOTA AND CHRONIC KIDNEY DISEASE. PART II. Nephrology (Saint-Petersburg). 2019;23(1):18-31. (In Russ.) https://doi.org/10.24884/1561-6274-2018-23-1-18-31
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