COLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASES INTESTINAL MICROBIOTA AND CHRONIC KIDNEY DISEASE. PART II
https://doi.org/10.24884/1561-6274-2018-23-1-18-31
Abstract
Interest in studying the role of the gastrointestinal tract in maintaining homeostasis in chronic kidney disease is a traditional one. It served, in particular, as a starting point for the creation of enterosorbents. However, if earlier the main attention was paid to the mechanical removal of a number of potentially dangerous biologically active substances, recently an intestinal microbiota has become an object of interest. The first part of the review of the literature on this topic is devoted to questions of terminology, the normal physiology of the colon microbiota. A detailed description of dysbiosis is given. The features of the main groups of microorganisms are reflected. The hypothetical and confirmed interrelations of the intestine-kidney axis are presented. The pathogenetic mechanisms of the influence of colon dysbiosis on the processes of local and systemic inflammation are discussed. The influence of dysbiosis on the state of the kidney parenchyma and its participation in the progression of CKD are debated.
About the Authors
B. G. Lukichev
Department of propedeutics of internal diseases of First Pavlov St-Petersburg State Medical University
Russian Federation
Russian Federation
Prof. Boris G. Lukichev MD, PhD, DMedSci
197022, St-Petersburg, L. Tolstoy st., 17, build. 54, First Pavlov St-Petersburg State Medical University, Department of propedeutics of internal diseases.
Phone: (812)-234-01-65
A. Sh. Rumyantsev
Department of propedeutics of internal diseases of First Pavlov St-Petersburg State Medical University; Department of Faculty Therapy of Saint Petersburg State University
Russian Federation
Russian Federation
Prof. Alexandr Sh.Rumyantsev MD, PhD, DMedSci
199106 Russia, Saint Petersburg, V.O., 21 line 8a. Saint Petersburg State University Department of Faculty Therapy
Phone: +7(812) 326-03-26
I. Yu. Panina
Department of propedeutics of internal diseases of First Pavlov St-Petersburg State Medical University
Russian Federation
Russian Federation
Prof. Irina Yu. Panina MD, PhD, DMedSci
197022, Russia, St-Petersburg, L. Tolstoy st., 17, build. 54, First Pavlov St-Petersburg State Medical University, Department of propedeutics of internal diseases.
Phone: (812)-234-01-65
V. Akimenko
Department of propedeutics of internal diseases of First Pavlov St-Petersburg State Medical University
Russian Federation
Russian Federation
Akimenko V.
197022, Russia, St-Petersburg, L. Tolstoy st., 17, build. 54, First Pavlov St-Petersburg State Medical University, Department of propedeutics of internal diseases.
Phone: (812)-234-01-65
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Review
For citations:
Lukichev B.G., Rumyantsev A.Sh., Panina I.Yu., Akimenko V. COLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASES INTESTINAL MICROBIOTA AND CHRONIC KIDNEY DISEASE. PART II. Nephrology (Saint-Petersburg). 2019;23(1):18-31. (In Russ.) https://doi.org/10.24884/1561-6274-2018-23-1-18-31
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