Clinical and functional peculiarities at patients with bronchial asthma, chronic obstructive pulmonary disease and overlap of asthma-chronic obstructive pulmonary disease
https://doi.org/10.36485/1561-6274-2020-24-4-80-86
Abstract
BACKGROUND: a comparative analysis of laboratory and instrumental tests at patients with bronchial obstructive diseases seems very actual due to the wide prevalence of these diseases.
THE AIM: to evaluate characteristics of spirometry as well as allergic (total IgE, sputum eosinophils) and infectious (blood and sputum leucocytes, ESR, CRP, fibrinogen) inflammation markers at patients with bronchial obstructive diseases.
PATIENTS AND METHODS: 104 case histories of patients with bronchial asthma, chronic obstructive pulmonary disease and overlap were analyzed including age, duration of smoking (pack-years), laboratory (clinical blood test, biochemical blood test, general sputum analysis, sputum culture) and instrumental (spirometry, body plethysmography, echocardiography) tests. Data were processed statistically with non-parametric methods.
RESULTS: COPD patients were older than other groups’ patients, had the highest pack-years index. ACO patients were marked with maximal TLC and Raw, minimal FEV1, FEF25-75, FEV1/FVC. Patients with COPD had the highest inflammation markers (leucocyte count, CRP, fibrinogen).
CONCLUSION: high active inflammation may cause severe lower airways possibility disorders at patients with COPD. Data related to a possible role of K. pneumoniaе in the pathogenesis of eosinophilic inflammation in lower airways are of significant interest. Patients with ACO occupy an intermediate position between asthma and COPD patients based on clinical and functional features.
About the Authors
V. I. Trofimov
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
Prof. Trofimov Vasilii Ivanovich, MD, PhD, SciD, Department of Hospital Therapy, professor, head of department
197022,St. Petersburg, L. Tolstoy st., 6-8, build 10
Tel.: 8 (921) 9131328
D. Z. Baranov
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
Baranov Dmitrii Zafarovich, MD, Department of Hospital Therapy, postgraduate student
197022, St. Petersburg, L. Tolstoy st., 6-8, build 10
Tel.: 8 (981) 9848126
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For citations:
Trofimov V.I., Baranov D.Z. Clinical and functional peculiarities at patients with bronchial asthma, chronic obstructive pulmonary disease and overlap of asthma-chronic obstructive pulmonary disease. Nephrology (Saint-Petersburg). 2020;24(4):80-86. (In Russ.) https://doi.org/10.36485/1561-6274-2020-24-4-80-86
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