Дигидропиридиновые блокаторы кальциевых каналов для нефропротективной терапии гипертензивных больных с хронической болезнью почек
https://doi.org/10.36485/1561-6274-2021-25-2-27-34
Аннотация
Амлодипин и селективные дигидропиридиновые блокаторы L-Са2+-каналов второго поколения при добавлении к ингибиторам АПФ или заменяющим их антагонистам АТ1-ангиотензиновых рецепторов не улучшают клинические почечные исходы у гипертензивных больных с хронической болезнью почек. Эти препараты не устраняют внутриклубочковую гипертензию, лежащую в основе гипертонической нефропатии, и могут оказывать неблагоприятное влияние на нейрогормональный статус организма, вызывая активацию симпатической и ренин-ангиотензин-альдостероновой систем. В обзоре представлены результаты клинических исследований, посвященных оценке эффективности применения в этой популяции пациентов нового дигидропиридинового блокатора L-Са2+-каналов третьего поколения лерканидипина, двойного блокатора T/L-Са2+-каналов бенедипина и двойного блокатора N/L-Са2+-каналов цилнидипина, отличающихся от своих предшественников выраженными нефропротективными свойствами.
Об авторах
О. Б. Кузьмин
Кафедра фармакологии Оренбургского государственного медицинского университета
Россия
Россия
Проф. Кузьмин Олег Борисович, д-р мед. наук
460000, Россия, г. Оренбург, Парковый пр., д. 7
Тел.: (8) 9198487679
В. В. Жежа
Кафедра фармакологии Оренбургского государственного медицинского университета
Россия
Россия
Жежа Владислав Викторович, канд. мед. наук
460000, Россия, г. Оренбург, Парковый пр., д. 7
Тел.: (8) 9510385128
В. В. Белянин
Кафедра фармакологии Оренбургского государственного медицинского университета
Россия
Россия
Белянин Виталий Васильевич канд мед наук
46000, Россия, Оренбург, Парковый пр., д. 7
Тел.: (8) 9878703415
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Рецензия
Для цитирования:
Кузьмин О.Б., Жежа В.В., Белянин В.В. Дигидропиридиновые блокаторы кальциевых каналов для нефропротективной терапии гипертензивных больных с хронической болезнью почек. Нефрология. 2021;25(2):27-34. https://doi.org/10.36485/1561-6274-2021-25-2-27-34
For citation:
Kuzmin O.B., Zhezha V.V., Belyanin V.V. Dihydropyridine calcium channel blockers for the renoprotective therapy of hypertensive patients with chronic kidney disease. Nephrology (Saint-Petersburg). 2021;25(2):27-34. (In Russ.) https://doi.org/10.36485/1561-6274-2021-25-2-27-34
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