The activity of the renin-aldosterone system and arterial hypertension creation in patients with congenital vesicoureteral reflux and reflux nephropathy
Abstract
THE AIM. To estimate contribution of renin and aldosteron in development of the arterial hypertension (AH) in children with congenital vesicoureteral reflux (VUR) and a reflux nephropathy without structural and functional changes. MATERIALS AND METHODS. 75 patients with VUR aged from 3 to 18 years were examined. Depending on existence of structural and functional changes 3 groups were allocated. The 1st group - 23 children with VUR without structural and functional changes; the 2nd group of - 29 children with reflux nephropathy without AH syndrome, the 3rd group - 23 patients with a reflux nephropathy and AH. Renin and aldosterone production was estimated on the basis of determination of renin and aldosterone levels in blood plasma (supine) by enzyme linked immunoadsorbent assay. RESULTS. Renin-aldosterone system activation in 68% of 51 patients with congenital VUR is revealed. Significantly higher concentrations of a renin and aldosterone, glomerular filtration rate reduction are established in patients with reflux nephropathy with AH, AH at 56,5% of patients is followed by a hypernatremia. CONCLUSION. Reflux nephropathy is associated with high concentrations of renin and aldosterone, as the pathogenic mechanisms of the nephrosclerosis and AH formation.
About the Authors
A. M. Mambetova
Kabardino-Balkarian state university named after H.M.Berbekov
Russian Federation
Russian Federation
A. M. Inarokova
Kabardino-Balkarian state university named after H.M.Berbekov
Russian Federation
Russian Federation
N. N. Shabalova
Saint-Petersburg state pediatric medical university
Russian Federation
Russian Federation
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Review
For citations:
Mambetova A.M., Inarokova A.M., Shabalova N.N. The activity of the renin-aldosterone system and arterial hypertension creation in patients with congenital vesicoureteral reflux and reflux nephropathy. Nephrology (Saint-Petersburg). 2016;20(5):30-35. (In Russ.)
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