Epigenetic mechanisms of nephroprotection in diabetic nephropathy: focus is on sirtuin-1
https://doi.org/10.36485/1561-6274-2021-25-6-9-15
Abstract
Numerous studies have shown the critical role of sirtuin-1 deacetylase (SIRT1) in the protection of renal cells from endogenous and exogenous stresses. A protective role for SIRT1 has been established in both podocytes and renal tubular cells in many kidney diseases, including diabetic nephropathy (DN). SIRT1 has also been shown to have nephroprotective effects in DN, in part through the deacetylation of transcription factors involved in disease pathogenesis, such as p53, FOXO, RelA / p65NF-KB, STAT3, and PGC1a / PPARy. Recently, it was found that podocyte-specific overexpression of SIRT1 attenuates proteinuria and kidney damage in an experimental model of DN, suggesting the possibility of using SIRT1 as a potential target for the treatment of kidney disease. In addition, SIRT1 agonists such as resveratrol and BF175 have been shown to reduce diabetic kidney damage in several experimental animal models. It has also been shown that puerarin, a Chinese herbal medicine, activates SIRT1, providing nephroprotection in a mouse model of DN. In addition to SIRT1 agonists, inhibitors of bromodomain, in particular, MS417, also have a nephroprotective effect. These results suggest that SIRT1 agonists and bromodomain inhibitors may be new potential therapeutic agents that slow the progression of DN.
About the Authors
K. A. Aitbaev
Research Institute of Molecular Biology and Medicine
Kazakhstan
Kazakhstan
Prof. Kubanych A. Aitbaev - Research Institute of Molecular Biology and Medicine at the National Center for Cardiology and Therapy named after academician Mirsaid Mirrakhimov, Head of the Department of Pathological Physiology. Member of the Board of the Society of Chronic Kidney Disease Specialists of Kyrgyzstan.
MD, PhD, DMedSci 720040, Bishkek, T. Moldo, Street, 3. Phone: (312) 66-25-13
I. T. Murkamilov
I.K. Akhunbaev Kyrgyz State Medical Academy
Kyrgyzstan
Kyrgyzstan
Ilkhom T. Murkamilov - MD, PhD, acting associate professor of the Department of faculty therapy of Kyrgyz SMA named after I.K. Akhunbaev, Senior lecturer of Kyrgyz-Russian SU. Chairman of the board of Chronic Kidney Disease specialists Society of Kyrgyzstan.
720020, Bishkek, Akhunbaev Street, 92. Phone: (312) 62-09-91
V. V. Fomin
Sklifosovsky Institute, I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Сorresponding member of RAS Viktor V. Fomin - MD, PhD. DMedSci, professor Head of the Department of Faculty Therapy No.1 of the Sklifos-ovsky Institute, Vice-rector in clinical work and continuous professional education, I.M. Sechenov First Moscow SMU (Sechenov University).
119146, Moscow, 6 Bolshaya Pirogovskaya, Street 6. Phone: +7 (499) 248-62-22
Zh. A. Murkamilova
Kyrgyz Russian Slavic University
Kyrgyzstan
Kyrgyzstan
Correspondence graduate student Zhamila A. Murkamilova – Department of Therapy No. 2 of the Medical Faculty, SEI HPE Kyrgyz-Russian SU.
720000, Bishkek, Kiev, Street, 44. Phone: (+996) 552435009
F. A. Yusupov
Osh State University
Kyrgyzstan
Kyrgyzstan
Prof. Furkat A. Yusupov - MD, PhD. Head of the Department of neurology, psychiatry and medicinal genetics of medicinal faculty of Osh State University. Board member of Chronic Kidney Disease specialists Society of Kyrgyzstan, Chief neurologist of Southern region of Kyrgyzstan.
714000, Osh, Lenin Street, 331. Phone: (+996) 557202071
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For citations:
Aitbaev K.A., Murkamilov I.T., Fomin V.V., Murkamilova Zh.A., Yusupov F.A. Epigenetic mechanisms of nephroprotection in diabetic nephropathy: focus is on sirtuin-1. Nephrology (Saint-Petersburg). 2021;25(6):9-15. (In Russ.) https://doi.org/10.36485/1561-6274-2021-25-6-9-15
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