Expression miRNA-21 in renal tissue and urine in rats with unilateral ureteral obstruction

AIM: to examine the effect of diets with different contents of sodium chloride on blood pressure (BP), remodeling of the myocardium and the parameters of sodium homeostasis in spontaneously hypertensive rats (SHR). MATERIAL AND METHODS. We studied two groups of animals. First group received during 2 months diet containing 0.34% NaCl, second - high salt diet (8.0 %) NaCl. The blood pressure (BP) was recorded at the end of the observation period. In serum and in daily urine sodium concentration was determined. The study of morphological changes in the myocardium was performed on the light-optical level. RESULTS. The level of BP did not differ between groups, myocardial mass index, left ventricular mass index, sodium concentration in the urine, daily urine volume and sodium excretion were higher in animals fed a diet containing 8% NaCl. In rats from this group increase of cardiomyocytes fibers hypertrophy severity, mild perivascular fibrosis and moderate hypertrophy of smooth muscle cells of the vessel walls were revealed. CONCLUSION. Results of the study suggest that the high sodium chloride diet in SHR rats leads to a unique profile of myocardial remodeling, which is not determined exclusively by the increase of blood pressure.

arterial hypertension, cardiac remodeling, diet, sodium chloride

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