CAKUT-SYNDROME IN THE ETIOLOGICAL STRUCTURE OF CHRONIC KIDNEY DISEASE IN CHILDREN AND ADOLESCENTS
https://doi.org/10.24884/1561-6274-2017-3-69-74
Abstract
THE AIM. To evaluate CAKUT-syndrome frequency in the etiological structure of chronic kidney disease (СKD) in children and adolescents.
PATIENTS AND METHODS. 80 children with CKD: 39 boys and 41 girls. 50 patients with predialysis stage, 30 dialysis patients, 21 of them on hemodialysis (HD), 9 peritoneal dialysis (PD). CKD diagnosis was established according to the recommendations K/DOQI (2006), Кidney Disease Improving Global Оutcomes (2012), NCGC(2015). Stages of CKD is classified in accordance with the recommendations K/DOQI (2006), NICE (2011); KDIGO (2012). Smirnov A.V., Shilov E.M., Dobronravov D.F. et al. (2012).
RESULTS. In the CKD etiological structure from 80 patients in 60 (75%) revealed congenital and hereditary diseases of kidneys among which CAKUT syndrome – in 34 (56, 5%).
CONCLUSION. It is established that in the etiological structure of CKD in children and adolescents is dominated by congenital and hereditary kidney diseases (75 %), among which prevails CAKUT-syndrome.
About the Authors
E. V. Lysova
Saint -Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
MD, Department of faculty pediatrics,
194100, St-Petersburg, Litovskaya st., 2
N. D. Savenkova
Saint -Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Prof., MD, PhD, DMedSci, Head of department of faculty pediatrics
194100, St-Petersburg, Litovskaya st., 2
References
1. K/DOOQ, Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation Classification Stratification. A J K D 2002; 39 (2 Suppl. 1): 1–266
2. KDIGO – Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International Supplements 2012; 2: 331–335
3. Смирнов АВ, Шилов ЕМ, Добронравов ВA. и др. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. Национальные рекомендации. Нефрология 2012; 16: 1: 89-115 [Smirnov AV, Shilov EM, Dobronravov VA et al. Chronic kidney disease: the basic principles of screening, diagnosis, prevention and treatment approaches. National guidelines. Nephrology 2012; 16: 1: 89-115]
4. Ингелфингер Д, Калантар-Заде К, Шефер Ф. Сосредоточим внимание на периоде детства, предотвратим последствия заболеваний почек. Нефрология 2016; 20(2):10-17 [Ingelfinger D, Kalantar-Zade K, Shefer F. Sosredotochim vnimanie na periode detstva, predotvratim posledstvija zabolevanij pochek. Nefrologija 2016; 20(2):10-17]
5. Ingelfinger ОR, Kalantar-Zadeh K, Schaefer F. World Kidney Day 2016: Averting the legacy of kidney disease – focus on childhood. Pediatr Nephrology 2016;31(3):343–348
6. Smith JM, Stablein DM, Munoz R et al. Contributions of the Transplant Registry: The 2006 Annual Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS). Pediatr Transplant 2007; 11(4):366-73
7. Ishikura К, Uemura O, Hamasaki Y et al. Insignificant impact of VUR on the progression of CKD in children with CAKUT. Pediatr Nephrol 2016; 31:105–112
8. Игнатова М.С. CAKUT-синдром у детей. Педиатрия 2012;91(6):141-144. [Ignatova M.S. CAKUT-sindrom u detej. Pediatrija 2012;91(6):141-144]
9. Cordell H, Darlay R, Charoen P et al. Whole-Genome Linkage and Association Scan in Primary, Nonsynndromatic Vesicoureteral Reflux. J Am Soc Nephrol 2010; 21:1: 113–123
10. Renkema KJ, Winpred PJ, Scovorodkin IN et al. Nonel Perspectives for undestending congenital anomalies of the kidney and urinary tract(CAKUT). Nephrol dial Transplant 2011; 26(14): 3841–3851
11. Brandstrom P, Esbjorner E, Herthelius M et al. The Swedish reflux trial in children: III. Urinary tract infection pattern. J Urol 2010; 184: 286–291
12. Swerkersson S, Jodal U, Sixt R et al. Relationship among vesicoureteral reflux, urinary tract infection and renal damage in children. J Urol 2007; 178: 647–651
13. Salo J, Ikaheimo R, Tapiainen T, Uhari M. Childhood urinary tract infections as a cause of chronic kidney disease. Pediatrics 2011;128: 840–847
14. Montini G, Tullus K, Hewitt I. Febrile urinary tract infections in children. N Engl J Med 2011; 365:239–250
15. Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics 2010; 126:1084–1091
16. Chen MJ, Cheng HL, Chiou YY. Risk factors for renal scarring and deterioration of renal function in primary vesico- ureteral reflux children: a long-term follow-up retrospective cohort study. PloS One 2013; 8(2):e57954
17. Sjostrom S, Jodal U, Sixt R et al. Longitudinal development of renal damage and renal function in infants with high grade vesicoureteral reflux. J Urol 2009; 181:2277– 2283
18. Nicolaou N, Renkema KY, Bongers EM et all. Genetic, environmental, and epigenetic factors involved in CAKUT. Nat Rev Nephrol 2015;11(12):720-31
19. Папаян АВ, Осипов ИБ, Валькович ЭИ, Левандовский А.Б. Врожденные пороки развития органов мочевой системы. В кн.: Клиническая нефрология детского возраста. Под редакцией Папаяна АВ, Савенковой НД. СПБ: Левша, 2008; 108-121 [Papajan AV, Osipov IB, Val’kovich JeI, Levandovskij AB. Vrozhdennye poroki razvitija organov mochevoj sistemy. V kn.: Klinicheskaja nefrologija detskogo vozrasta. Pod redakciej Papajana AV, Savenkovoj ND SPB: Levsha, 2008; 108-121]
20. Игнатова М.С. Дизэмбиогенез органов мочевой системы и нефропатии. В кн.: Детская нефрология: Руководство для врачей. 3-е изд. Под ред. М.С. Игнатовой. М.: МИА, 2011: 10–15 [Ignatova M.S. Dizjembiogenez organov mochevoj sistemy i nefropatii. V kn.: Detskaja nefrologija: Rukovodstvo dlja vrachej. 3-e izd. Pod red. M.S. Ignatovoj. M.: MIA, 2011: 10–15]
21. Rodriguez MM. Congenital Anomalies of the Kidney and the Urinary Tract (CAKUT). Fetal Pediatr Pathol 2014; 33(5-6): 293–320
22. Weber S. Noval genetic aspects of congenital anomalies of kidney and urinary tract. Curr Opin Pediatr 2012; 24 (2): 212–218
23. Комарова ОВ, Цыгин АН, Намазова-Баранова ЛС, Баранов АА. Скорость прогрессирования хронической болезни почек различной этиологии у детей. Нефрология 2016; 20(2):53-58 [Komarova OV, Cygin AN, Namazova-Baranova LS, Baranov AA. Skorost’ progressirovanija hronicheskoj bolezni pochek razlichnoj jetiologii u detej. Nefrologija 2016; 20(2):53-58]
Review
For citations:
Lysova E.V., Savenkova N.D. CAKUT-SYNDROME IN THE ETIOLOGICAL STRUCTURE OF CHRONIC KIDNEY DISEASE IN CHILDREN AND ADOLESCENTS. Nephrology (Saint-Petersburg). 2017;21(3):69-74. (In Russ.) https://doi.org/10.24884/1561-6274-2017-3-69-74
Views:
9184
Email this article 