PLATELET AGGREGATION IN PATIENTS ON HEMODIALYSIS
https://doi.org/10.24884/1561-6274-2017-21-4-79-83
Abstract
Thromboembolic complications in patients on hemodialysis have a significant impact on the duration and quality of life of patients. THE AIM: to study the functional status of platelets at the CKD 5d. PATIENTS AND METHODS. We examined 61 patients with CKD 5d. The duration of renal replacement therapy 133 [74-177] months. The functional activity of platelets was evaluated in the samples with adenosine diphosphate and adrenaline. RESULTS. The average value of platelet aggregation in the sample with adenosine diphosphate was 59.5 [of 32.5 and 87.5]%. The functional activity of platelets was decreased in 35 of patients and not changed in 26 patients. The average value of platelet aggregation in the sample with epinephrine accounted for 68.5 [57,5-73,5]%. The functional activity of platelets was reduced in 38, normal in 8 and increased in 15 patients. CONCLUSION. Test with adrenaline is preferred in the study of the functional activity of platelets in CKD 5d.
About the Authors
K. N. Zelenin
First city clinical hospital named after E. E. Volosevich;
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
MD
Russia, 163001, Arkhangelsk, Suvorov str., 1 First city clinical hospital named after E. E. Volosevich, hemodialysis unit, chief. Phone: (8182) 27-67-72, 63-27-34
A. M. Esayan
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Prof.,MD, PhD, DMedSci
Russia, 197022, St-Petersburg, L’va Tolstogo str. 6-8 Pavlov First Saint Petersburg State Medical University, Department of nephrology and dialysis, chief. Phone (812) 234- 91-91
A. Sh. Rumyantsev
Saint Petersburg State University;
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
Prof., MD, PhD, DMedSci
Russia, 199106, Saint Petersburg, V.O., 21 line 8a. Saint Petersburg State University, Department of Faculty Therapy. Pavlov First Saint-Petersburg State Medical University, Department of propedeutic of internal diseases. Phone: +7(812) 326-03-26
References
1. Thomas M, Nesbitt C, Ghouri M, Hansrani M. Maintenance of Hemodialysis Vascular Access and Prevention of Access Dysfunction: A Review. Ann Vasc Surg 2017 May 4. pii: S0890-5096(16)30813-5. doi: 10.1016/j.avsg.2017.02.014. [Epub ahead of print]
2. Martinović Z, Basić-Jukić N, Pavlović DB, Kes P. Importance of platelet aggregation in patients with end-stage renal disease. Acta Clin Croat 2013;52(4):472-477
3. Waki K, Hayashi A, Ikeda S, Ikeda S et al. Measuring platelet aggregation in dialysis patients with a whole blood aggregometer by the screen filtration pressure method. Ther Apher Dial 2011;15(2):203-6. doi: 10.1111/j.1744-9987.2010.00899.x
4. Daugirdas JT. Second generation logarithmic estimates of single-pool variable volume Kt-V: An analysis of error. J Am Soc Nephrol 1993; 4: 1205–1213
5. Bauer A, Limperger V, Nowak-Göttl U End-stage renal disease and thrombophilia. Hamostaseologie 2016 May 10; 36(2):103-7. doi: 10.5482/HAMO-14-11-0063
6. Dolan AT, Diamond SL. Systems Modeling of Ca2+ Homeostasis and Mobilization in Platelets Mediated by IP3 and StoreOperated Ca2+ Entry. Biophys J 2014 May 6; 106(9): 2049–2060.10.1016/j.bpj.2014.03.028
7. Mahaut-Smith MP1, Jones S, Evans RJ. The P2X1 receptor and platelet function. Purinergic Signal 2011;7(3):341-56. doi: 10.1007/s11302-011-9224-0
8. Purvis JE, Chatterjee MS, Brass LF, Diamond SL. A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation. Blood 2008 Nov 15; 112(10): 4069–4079. doi: 10.1182/blood-2008-05-157883
9. Passacquale G, Ferro A. Current concepts of platelet activation: possibilities for therapeutic modulation of heterotypic vs. homotypic aggregation. Br J Clin Pharmacol 2011;72(4):604-18. doi: 10.1111/j.1365-2125.2011.03906.x
Review
For citations:
Zelenin K.N., Esayan A.M., Rumyantsev A.Sh. PLATELET AGGREGATION IN PATIENTS ON HEMODIALYSIS. Nephrology (Saint-Petersburg). 2017;21(4):79-83. (In Russ.) https://doi.org/10.24884/1561-6274-2017-21-4-79-83
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