HOMOCYSTEINE LEVEL IN CHILDREN WITH CHRONIC KIDNEY DISEASE ON THE BACKGROUND OF CONGENITAL MALFORMATIONS OF THE URINARY SYSTEM
https://doi.org/10.24884/1561-6274-2018-22-1-98-103
Abstract
The aim: to evaluate diagnostic and prognostic value of determination the concentration of homocysteine in children with congenital malformations (CM) of the urinary system (US) dependent of kidneys functional state.
Patients and methods. The study included 119 patients with US CM aged 3 to 18 years. A control group of 10 clinically healthy children. Patients divided into 3 groups: group I – 55 children with congenital vesicoureteral reflux (VUR), group II – 34 children with hydronephrosis and ureterohydronephrosis of congenital origin, group III – 30 children with other forms of US dysembryogenesis. Concentration of homocysteine in blood serum was assessed by ELISA.
Results. Hyperhomocysteinemia diagnosed in 60,9% of cases. Statistically significant differences with control group were revealed in the obstructive types where more often arterial hypertension (AH) and reduced glomerular filtration rate (GFR) were diagnosed. Significantly higher concentration of homocysteine are registered in patients with hypertension and reduced GFR.
Conclusion. The importance of estimating concentration of homocysteine in chronic kidney disease in patients with US CM was demonstrated.About the Authors
A. M. Mambetova
Kabardino-Balkarian state university of Education and Science ministry’s of Russian Federation
Russian Federation
Russian Federation
Aneta M. Mambetova - MD, PhD, DMedSci, Prof., Department of general practice, gerontology, public health and health care.
360000 Nalchik, Chernyshevskaya street, 173, +78662421186, mobile +79054391190
A. M. Inarokova
Kabardino-Balkarian state university of Education and Science ministry’s of Russian Federation
Russian Federation
Russian Federation
Alla M. Inarokova - MD, PhD, DMedSci, Professor, Department of general practice, gerontology, public health and health care, chief.
360000, Nalchik, Chernyshevskaya street, 173, +7 +78662730368
N. N. Shabalova
Saint-Petersburg state pediatric medical university
Russian Federation
Russian Federation
Nina N. Shabalova - MD, PhD, Associate Professor, Department of pathophysiology with a course of immunopathology.
194100, Saint Petersburg, Litovskaya street, 2, +78125428882
A. T. Mahieva
North-Caucasian Nephrology center
Russian Federation
Russian Federation
Mahieva Aziza Tahirovna - Dialysis Unit , chief.
361330, KBR, Nartkala, Kahunskaya street, 61, +7980750929
References
1. Смирнов АВ. Шилов ЕМ, Добронравов ВА и др. Национальные рекомендации. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. Левша, СПб., 2013, 51 [Smirnov AV, SHilov EM, Dobronravova VA i dr. Nacional’nye rekomendacii. Hronicheskaya bolezn’ pochek: osnovnye principy skrininga, diagnostiki, profilaktiki i podhody k lecheniyu. SPb.: Levsha, 2013. 51]
2. Шилов ЕМ, Швецов МЮ, Бобкова ИН и др. Хроническая болезнь почек и нефропротективная терапия: Руководство для врачей М., 2012. 76. [Shilov EM, Shvecov MJu, Bobkova IN I dr. Hronicheskaja bolezn’ pochek i nefroprotektivnaja terapija: metod. rukovodstvo dlja vrachej – Chronic kidney disease and renoprotective therapy: method. a guide for physicians. M., 2012. 76]
3. Эрман МВ. Нефрология детского возраста: руководство для врачей. 2-е издание, Спец.Лит., СПб., 2010, 683. [Erman MV. Nefrologiya detskogo vozrasta: rukovodstvo dlya vrachej. 2-e izdanie, SPb.: Spec.Lit., 2010. 683]
4. Папаян АВ, Савенкова НД. Клиническая нефрология детского возраста. Руководство для врачей. Левша, СПб., 2008. 600. [Papayan AV, Savenkova ND. Klinicheskaya nefrologiya detskogo vozrasta. Rukovodstvo dlya vrachej. SPb.: Levsha, 2008. 600]
5. North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) 2008 Annual report. 2008. The EMMES Corporation, Rockville, MD. URL: https://web.emmes.com/study/pedannlrept/Annual%20Report%20-2008.pdf webcite. Accessed 24/01/2014
6. Добронравов ВА, Жлоба АА, Трофименко ИИ. Гипергомоцистеинемия как системная проблема с точки зрения нефролога. Нефрология 2006;10(2):7–17. [Dobronravov VA, ZHloba AA, Trofimenko II. Gipergomocisteinemiya kak sistemnaya problema s tochki zreniya nefrologa. Nefrologiya. 2006;10(2):7–17]
7. Arnadottir M, Hultberg, Nilsson-Ehle P et al. The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Invest 1996;56(1):41–46
8. Баканов МИ, Цыгин АН, Алатырцев ВВ и др. Гомоцистеин и функциональное состояние почек у детей с нефротическим синдромом. Педиатрическая фамакология 2013;6(10):60-63. [Bakanov MI, Cygin AN, Alatyrcev VV i dr. Gomocistein i funkcional’noe sostoyanie pochek u detej s nefroticheskim sindromom. Pediatricheskaya famakologiya. 2013;6(10):60-63]
9. Шевченко ОП. Гомоцистеин – новый фактор риска атеросклероза и тромбоза. Клиническая лабораторная диагностика 2004;10:25-31. [SHevchenko OP. Gomocistein — novyj faktor riska ateroskleroza i tromboza. Klinicheskaya laboratornaya diagnostika. 2004;10:25-31]
10. Шевченко ОП, Олефиренко ГА. Гипергомоцистеинемия и ее клиническое значение. Лаборатория 2002;1:3-7. [SHevchenko OP, Olefrienko GA. Gipergomocisteinemiya i ee klinicheskoe znachenie. Laboratoriya. 2002;1:3-7]
11. Золотухин ПВ, Чмыхало ВК, Макаренко МС и др. Положительный контур мочевой кислоты, гомоцистеина, NOX и XOR: нефрологические аспекты. Нефрология 2014;18(5):16-
12. [Zolotukhin PV, Chmykhalo VK, Makarenko MS i dr. Рositive loop of uric acid, homocysteine, and NOX and XOR enzymes: implications in nephrology. Nephrology (Saint-Petersburg). 2014;18(5):16-22 (In Russ.)]
13. Смирнов АВ, Добронравов ВА, Каюков ИГ. Кардиоренальный континуум: патогенетические основы превентивной нефрологии. Нефрология 2005;3:7-15. [Smirnov AV, Dobronravov VA, Kayukov IG. Kardio-renal’nyj kontinuum: patogeneticheskie osnovy preventivnoj nefrologii. Nefrologiya 2005;3:7-15]
14. Celedon CG, Bitsori M, Tullus K. Progression of chronic renal failure in children with dysplastic kidneys. Pediatric Nephrol 2007;22:1014-1020
15. Homocysteine and endothelial function in human studies. Moat SJ, McDowell IF. Semin Vasc Med 2005;5(2):172-182
16. Yang X, Li Y, Li Y et al. Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies. Front Physiol 2017;8:600. doi: 10.3389/fphys.2017.00600
Review
For citations:
Mambetova A.M., Inarokova A.M., Shabalova N.N., Mahieva A.T. HOMOCYSTEINE LEVEL IN CHILDREN WITH CHRONIC KIDNEY DISEASE ON THE BACKGROUND OF CONGENITAL MALFORMATIONS OF THE URINARY SYSTEM. Nephrology (Saint-Petersburg). 2018;22(1):98-103. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-1-98-103
Views:
1529
Email this article 