О ФУНКЦИОНАЛЬНОЙ РОЛИ ЦЕНТРАЛЬНЫХ МИНЕРАЛОКОРТИКОИДНЫХ РЕЦЕПТОРОВ И ВОЗМОЖНОСТЯХ ИХ ФАРМАКОЛОГИЧЕСКОЙ РЕГУЛЯЦИИ

минералкортикоидные рецепторы, глюкортикоидные рецепторы, альдостерон, головной мозг

1. Brilla CG, Schencking M, Scheer C, Rupp H. Spironolactone: renaissance of anti-aldosterone therapy in heart failure? Schweiz Rundsch Med Prax 1997; 86 (14): 566-574

2. Моисеев СВ. Спиронолактон (альдактон) в лечении сердечной недостаточности (исследование RALES). Клин фармакол и терап 1999; 8 (6): 46-51

3. Зверев ЯФ, Брюханов ВМ. Спиронолактон в комплексной терапии хронической сердечной недостаточности. Современные патогенетические подходы. Клинич фармакол и терап 2000; 9 (4): 46-52

4. Зверев ЯФ, Брюханов ВМ. Фармакология и клиническое использование экстраренального действия диуретиков.Медицинская книга, М., Изд-во НГМА, Н.Новгород, 2000; 61-81

5. Stier CTJr, Koenig S, Lee DY et al. Aldosterone and aldosterone antagonism in cardiovascular disease: focus on eplerenone (Inspra). Heart Dis 2003; 5 (2): 102-118

6. Brennan BJ, Martin NE. Eplerenone: selective aldosterone antagonism in management of cardiovascular and renal disease. J Am Pharm Assoc (Wash DC) 2004; 44 (5): 604-610

7. Jackiewicz E, Szczepanska-Sadowska E, Maslinski W. Expression of mineralocorticoid receptors mRNA in the brain, heart and kidney of Sprague Dawley rats with renovascular hypertension. Brain Res Bull 2005; 65 (1): 23-29

8. Stier CTJr, Rocha R, Chander PN. Effect of aldosterone and MR blockade on the brain and the kidney. Heart Fail Rev 2005; 10 (1): 53-62

9. Luttge WG, Rupp ME, Davda MM. Aldosterone-stimulated down-regulation of both type I and II adrenocorticosteroid receptors in mouse brain is mediated via type I receptors. Endocrinology 1989; 125 (2): 817-824

10. Agarwal MK, Mirshahi F, Mirshahi M, Rostene W. Immunochemical detection of mineralocorticoid receptor in rat brain. Neuroendocrinology 1993; 58 (5): 575-580

11. Sanchez MM, Young LJ, Plotsky PM, Insel TR. Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation. J Neurosci 2000; 20 (12): 4657-4668

12. Kretz O, Schmid W, Berger S, Gass P. The mineralocorticoid receptor expression in the mouse CNS is conserved during development. Neuroreport 2001; 12 (6): 1133-1137

13. Hansson AC, Fuxe K. Biphasic autoregulation of mineralocorticoid receptor mRNA in the medial septal nucleus by aldosterone. Neuroendocrinology 2002; 75 (6): 358-366

14. de Kloet ER, Van Acker SA, Sibug RM et al. Brain mineralocorticoid receptors and centrally regulated functions. Kidney Int 2000; 57 (4): 1329-1336

15. Datson NA, van der Perk J, de Kloet ER, Vreugdenhil E. Identification of corticosteroid-responsive genes in rat hyppocampus using serial analysis of gene expression. Eur J Neurosci 2001; 14 (4): 675-689

16. Funder JW, Sheppard K. Adrenocortical steroids and the brain. Annu Rev Physiol 1987; 49: 397-411

17. Oitzl MS, Fluttert M, de Kloet ER. The effect of corticosterone on reactivity to spatial novelty is mediated by central mineralocorticosteroid receptors. Eur J Neurosci 1994; 6 (7): 1072-1079

18. Kalman BA, Spencer RL. Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain. Endocrinology 2002; 143 (11): 4184-4195

19. Арушанян ЭБ, Бейер ЭВ. Место гиппокампа в био-ритмологической организации поведения. Успехи физиол наук 2001; 32 (1): 79-95

20. Чирков АМ, Цулая МГ, Чиркова СК и др. Психофармакология эмоционального стресса у обезьян.Изд-во Мецниереба, Тбилиси, 1989; 245-315

21. Филаретов АА. Закономерности функционирования гипоталамо-гипофизарно-адренокортикальной системы. Успехи физиол наук 1993; 24 (2): 70-83

22. Арушанян ЭБ. Хронофармакология. Изд-во СГМА, Ставрополь, 1999; 14-27, 75-85

23. Deuschle M, Weber B, Colla M et al. Mineralocorticoid receptor also modulates basal activity of hypothalamus-pituitary-adrenocortical system in humans. Neuroendocrinology 1998; 68 (5): 355-360

24. Arvat E, Maccagno B, Giordano R et al. Mineralocorticoid receptor blockade by canrenoate increases both spontaneous and stimulated adrenal function in humans. J Clin Endocrinol Metab 2001; 86 (7): 3176-3181

25. Ratka A, Sutanto W, Bloemers M, de Kloet ER. On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation. Neuroendocrinology 1989; 50 (2): 117-123

26. Young EA, Lopez JF, Murphy Weinberg V et al. The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans. J Clin Endocrinol Metab 1998; 83 (9): 3339-3345

27. Heuser I, Deuschle M, Weber A et al. The role of mineralocorticoid receptors in the circadian activity of the human hypothalamus-pituitary-adrenal system: effect of age. Neurobiol Aging 2000; 21 (4): 585-589

28. van Haarst AD, Oitzl MS, de Kloet ER. Facilitation of feedback inhibition through blockade of glucocorticoid receptors in the hippocampus. Neurochem Res 1997; 22 (11): 1323-1328

29. Spencer RL, Kim PJ, Kalman BA, Cole MA. Evidence for mineralocorticoid receptor facilitation of glucocorticoid receptor-dependent regulation of hypothalamic-pituitary-adrenal axis activity. Endocrinology 1998; 139 (6): 2718-2726

30. Cole MA, Kim PJ, Kalman BA, Spencer RL. Dexamethasone suppression of corticosteroid secretion: evaluation of the site of action by receptor measures and functional studies. Psychoneuroendocrinology 2000; 25 (2): 151-167

31. Schmidt M, Oitzl MS, Muller MB et al. Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. Neuroscience 2003; 119 (2): 589-595

32. Schmidt MV, Levine S, Oitzl MS et al. Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse. Endocrinology 2005; 146 (3): 1458-1464

33. de Kloet ER. Stress in the brain. Eur J Pharmaco l2000; 405 (1-3): 187-198

34. Nishi M, Kawata M. Corticosteroid receptor and stress. Nihon Shinkei Seishin Yakurigaku Zasshi 2000; 20 (5): 181-188

35. Joles M. Corticosteroid actions in the hippocampus. J Neuroendocrinol 2001; 13 (8): 657-669

36. van den Buuse M, van Acker SA, Fluttert MF, de Kloet ER. Involvement of corticosterone in cardiovascular responses to an open-field novelty stressor in freely moving rats. Physiol Behav 2002; 75 (1-2):207-215

37. De Kloet ER. Hormones, brain and stress. Endocr Regul 2003; 37 (2): 51-68

38. De Kloet ER. Hormones and the stressed brain. Ann NY Acad Sci 2004; 1018: 1-15

39. De Kloet ER, Derijk R. Signaling pathways in brain involved in predisposition and pathogenesis of stress-related disease: genetic and kinetic factors affecting the MR/GR balance. Ann NY Acad Sci 2004; 1032: 14-34

40. Takeda H, Tsuji M, Matsumiya T. Formation mechanisms of stress adaptation: role of functional coupling of glucocorticoids and brain serotonergic nervous system. Nihon Shinkei Seishin Yakurigaku Zasshi 2000; 20 (3): 83-91

41. Young EA, Lopez JF, Murphy-Weinberg V et al. Mineralocorticoid receptor function in major depression. Arch Gen Psychiatry 2003; 60 (1): 24-28

42. Xing GQ, Russel S, Webster MJ, Post RM. Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorders. Int Neuropsychopharmacol 2004; 7 (2): 143-153

43. Herman JP, Spencer R. Regulation of hippocampal glucocorticoid receptor gene transcription and protein expression in vivo. J Neurosci 1998; 18 (18): 7462-7473

44. Nishi M, Takeda M, Matsuda K et al. Visualization of glucocorticoid receptor and mineralocorticoid receptor interactions in living cells with GFP-based fluorescence resonance energy transfer. J Neurosci 2004; 24 (21): 4918-4927

45. Cole MA, Kalman BA, Pace TW et al. Selective blockade of the mineralocorticoid receptor impairs hypothalamic-pituitary-adrenal axis expression of habituation. Neuroendocrinol 2000; 12 (10): 1034-1042

46. Виноградова ОС. Гиппокамп и память.Наука, М., 1975; 81-156

47. Vanderwolf C, Kelly M, Kraemer P, Streather A. Are emotion and motivation localized in the limbic system and nucleus accumbens? Behav Brain Res1988; 27 (1): 45-58

48. Симонов ПВ. О нервных центрах эмоций. Журн высш нервн деят 1993; 43 (3): 514-529

49. Симонов ПВ. Мозговые механизмы эмоций. Журн высш нервн деят 1997; 47 (2): 320-328

50. Туманян ВА. Активность нейронов гиппокампа и височной коры в процессе обучения. Изд-во АН Армянской ССР, Ереван, 1988; 85-180

51. Haller J, Millar S, Kruk MR. Mineralocorticoid receptor blockade inhibits aggressive behaviour in male rats. Stress 1998; 2 (3): 201-207

52. Haller J, Millar S, van de Schraaf J et al. The active phase-related increase in corticosterone and aggression are linked. J Neuroendocrinol 2000; 12 (5): 431-436

53. Korte SM, de Boer SF, de Kloet ER, Bohus B. Anxiolytic-like effects of selective mineralocorticoid and glucocorticoid antagonists on fear-enhanced behavior in the elevated plus-maze. Psychoneuroendocrinology 1995; 20 (4): 385-394

54. Bitran D, Shiekh M, Dowd JA et al. Corticosterone is permissive to the anxiolytic effect that results from the blockade of hippocampal mineralocorticoid receptors. Pharmacol Biochem Behav1998; 60 (4): 879-887

55. Smythe JW, Murphy D, Timothy C, Costall B. Hippocampal mineralocorticoid, but not glucocorticoid, receptors modulate anxiety-like behavior in rats. Pharmacol Biochem Behav 1997; 56 (3): 507-513

56. Murphy D, Costall B, Smythe JW. Regulation of hippocampal theta activity by corticosterone: opposing functions of mineralocorticoid and glucocorticoid receptors. Brain Res Bull 1998; 45 (6): 631-635

57. Douma BR, Jansen K, Korte SM et al. Corticosterone modifies muscarinic receptor immunoreactivity in rat hippocampus. Neurosci Lett 1999; 268 (1): 41-44

58. Meijer OC, Williamson A, Dallman MF, Pearce D. Transcriptional repression of the 5-HT 1 A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context. J Neuroendocrinol 2000; 12 (3): 245-254

59. Wissink S, Meijer O, Pearce D et al. Regulation of the rat serotonin-1A receptor gene by corticosteroids. J Biol Chem 2000; 275 (2): 1321-1326

60. Joels M, Van Riel E. Mineralocorticoid and glucocorticoid receptor-mediated effects of serotonergic transmission in health and disease. Ann NY Acad Sci 2004; 1032: 301-303

61. Mitchell JB, Betito K, Rowe W et al. Serotonergic regulation of type II corticosteroid receptor binding in hippocampal cell cultures: evidence for the importance of serotonin-induced changes in cAMP levels. Neuroscience 1992; 48 (3): 631-639

62. Lai M, McCormick JA, Chapman KE et al. Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal cultures. Neuroscience 2003; 118 (4): 975-984

63. Yau JL, Hibberd C, Noble J, Seckl JR. The effect of chronic fluoxetine treatment of brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats. Brain Res 2002; 106 (1-2): 117-123

64. Buwalda B, de Boer SF, Schmidt ED et al. Long-lasting deficient dexamethasone suppression of hypothalamic-pituitary-adrenocortical activation following peripheral CRF challenge in socially defeated rats. J Neuroendocrinol 1999; 11 (7): 513-520

65. Okugawa G, Omori K, Suzukawa J et al. Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurons. J Neuroendocrinol 1999; 11 (11): 887-895

66. Heuser I, Deuschle M, Weber B et al. Increased activity of the hypothalamus-pituitary-adrenal system after treatment with the mineralocorticoid receptor antagonist spironolactone. Psychoneuroendocrinology 2000; 25 (5): 513-518

67. Reul JM, Gesing A, Droste S et al. The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. Eur J Pharmacol 2000; 405 (1-3): 235-249

68. Gesing A, BilangBleuel A, Droste SK et al. Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotrophin-releasing hormone. J Neurosci 2001; 21 (13): 4822-4829

69. Meyer U, van Kampen M, Isovich E et al. Chronic psychosocial stress regulates the expression of both GR and MR mRNA in the hippocampal formation of tree shrews. Hippocampus 2001; 11 (3): 329-336

70. Keck ME, Wigger A, Welt T et al. Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders. Neuropsychopharmacology 2002; 26 (1): 94-105

71. Smriga M, Nishiyama N, Saito H. Mineralocorticoid receptor-mediated enhancement of neuronal excitability and synaptic plasticity in the dentate gyrus in vivo is dependent on the beta-adrenergic activity. J Neurosci Res 1998; 51 (5): 593-601

72. Huang BS, Leenen FH. Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI. Am J Physiol Heart Circ Physiol 2005; 288 (5): H2491-H2497

73. Lupien SJ, Wilkinson CW, Briere S et al. The modulatory effects of corticosteroids on cognition: studies in young human populations. Psychoneuroendocrinology 2002; 27 (3): 401-416

74. Meijer OC, Topic B, Steenbergen PJ et al. Correlations between hypothalamus-pituitary-adrenal axis parameters depend on age and learning capacity. Endocrinology 2005; 146 (3): 1372-1381

75. Sandi C, Rose SP. Corticosteroid receptor antagonists are amnestic for passive avoidance learning in day-old chicks. Eur J Neurosci 1994; 6 (8): 1292-1297

76. Losertales M, Rose SP, Daisley JN, Sandi C. Piracetam facilitates long-term memory for a passive avoidance task in chicks through a mechanism that requires a brain corticosteroid action. Eur J Neurosci 1998; 10 (7): 2238-2243

77. Douma BR, Korte SM, Buwalda B et al. Repeated blockade of mineralocorticoid receptors, but not of glucocorticoid receptors impairs food rewarded spatial learning. Psychoneuroendocrinology 1998; 23 (1): 33-44

78. Yau JL, Noble J, Seckl JR. Continuous blockade of brain mineralocorticoid receptors impairs spatial learning in rats. Neurosci Lett 1999; 277 (1): 45-48

79. Smythe JW, Murphy D, Timothy C et al. Cognitive dysfunctions induced by scopolamine are reduced by systemic or intrahippocampal mineralocorticoid receptors blockade. Pharmacol Biochem Behav 1997; 56 (4): 613-621

80. Frishman WH, Stier CTJr. Aldosterone and aldosterone antagonism in systemic hypertension. Curr Hypertens Rep 2004; 6 (3): 195-200

81. Gomez-Sanchez EP. Brain mineralocorticoid receptors: orchestrators of hypertension and end-organ disease. Curr Opin Nephrol Hypertens 2004; 13 (2): 191-196

82. Van den Berg DT, de Kloet ER, van Dijken HH, de Jong W. Differential central effects of mineralocorticoid and glucocorticoid agonists and antagonists on blood pressure. Endocrinology 1990; 126 (1): 118-124

83. Van den Berg DT, de Jong W, de Kloet ER. Mineralocorticoid antagonist inhibits stress-induced blood pressure response after repeated daily warning. Am J Physiol 1994; 267 (6): E921-E926

84. Van den Berg DT, de Kloet ER, de Jong W. Central effects of mineralocorticoid antagonist RU 28318 on blood pressure of DOCA-salt hypertensive rats. Am J Physiol 1994; 267 (6): E927-E933

85. Rahmouni K, Sibug RM, De Kloet ER et al. Effects of brain mineralocorticoid receptor blockade on blood pressure and renal functions in DOCA-salt hypertension. Eur J Pharmacol 2002;436 (3): 207-216

86. Gomez-Sanchez EP, Fort C, Thwaites D. Central mineralocorticoid receptor antagonism blocks hypertension in Dahl S/JR rats. Am J Physiol1992; 262 (1): E96-E99

87. Young M, Head G, Funder J. Determinants of cardiac fibrosis in experimental hypermineralocorticoid states. Am J Physiol 1995; 269 (4): E657-E662

88. Rahmouni K, Barthelmebs M, Grima M et al. Influence of sodium intake on the cardiovascular and renal effects of brain mineralocorticoid receptor blockade in normotensive rats. J Hypertens 2002; 20 (9): 1829-1834

89. Gomez-Sanchez EP, Gomez-Sanchez CE. Central hypertensiogenic effects of glycyrrhizic acid and carbenoxolone. Am J Physiol 1992; 263 (6): E1125-E1130

90. Stienstra CM, Jouls M. Effect of corticosteroid treatment in vitro on adrenalectomy-induced impairment of synaptic transmission in the rat dentate gyrus. J Neuroendocrinol 2000; 12 (3): 199-205

91. Sousa N, Almeida OF. Corticosteroids: sculptors of the hippocampal formation. Rev Neurosci 2002; 13 (1): 59-84

92. McCullers DL, Herman JP. Mineralocorticoid receptors regulate bcl2 and p 53 mRNA expression in hippocampus. Neuroreport 1998; 9 (13): 3085-3089

93. Almeida OF, Condu GL, Crochemore C et al. Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J2000; 14 (5): 779-790

94. Fischer AK, von Rosenstiel P, Fuchs E et al. The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat. Brain Res 2002; 947 (2): 290-293

95. Macleod MR, Johansson IM, Soderstrom I et al. Mineralocorticoid receptor expression and increased survival following neuronal injury. Eur J Neurosci 2003; 17 (8): 1549-1555

96. McCullers DL, Herman JP. Adrenocorticosteroid receptor blockade and excitotoxic challenge regulate adrenocorticosteroid receptor mRNA levels in hippocampus. J Neurosci Res 2001; 64 (3): 277-283

97. McCullers DL, Sullivan PG, Scheff SW, Herman JP. Mifepristone protects CA1 hippocampal neurons following traumatic brain injury in rat. Neuroscience 2002; 109 (2): 219-230

98. McCullers DL, Sullivan PG, Scheff SW, Herman JP. Traumatic brain injury regulates adrenocorticosteroid receptor mRNA levels in rat hippocampus. Brain Res 2002; 947 (1): 41-49

99. Pedersen WA, McCullers D, Culmsee C et al. Corticotropinreleasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer’s disease. Neurobiol Dis 2001; 8 (3): 492-503