Protein markers iga-nephropathy, and focal segmental glomerulosclerosis by mass spectrometry
Abstract
THE AIM: to search noninvasive diagnostic IgA-nephropathy and focal segmental glomerulosclerosis (FSGS) based at proteomic studies of urine. PATIENTS AND METHODS. The study included 61 patients, who were divided into two groups. The first group included 31 patients with FSGS and 30 patients with IgA-nephropathy. All patients underwent general clinical research methods (complete blood count, urinalysis, blood creatinine concentration with the definition of the glomerular filtration rate) and mass spectrometry of urine. RESULTS. It was identified clinical and laboratory signs of glomerulonephritis: hypertension, azotemia, proteinuria, hematuria, decreased glomerular filtration rate. It was identified pathogenetic features of IgA-nephropathy and FSGS, with highlighting the functional groups of protein markers that reflect the way the progression of glomerulonephritis. CONCLUSION. Proteomic analysis of the spectrum of urine of patients with IgA-nephropathy and FSGS allows to use the proteins as potential markers of the progression of glomerulonephritis.
About the Authors
N. A. Bronovitskaya
Ростовский государственный медицинский университет
Russian Federation
Russian Federation
M. M. Batyushin
Ростовский государственный медицинский университет
Russian Federation
Russian Federation
I. V. Sarvilina
Медицинский центр «НОВОМЕДИЦИНА»
Russian Federation
Russian Federation
D. G. Pasechnik
Ростовский государственный медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Bronovitskaya N.A., Batyushin M.M., Sarvilina I.V., Pasechnik D.G. Protein markers iga-nephropathy, and focal segmental glomerulosclerosis by mass spectrometry. Nephrology (Saint-Petersburg). 2014;18(5):28-34. (In Russ.)
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