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СТРЕСС ЭНДОПЛАЗМАТИЧЕСКОГО РЕТИКУЛУМА ГЛАЗАМИ НЕФРОЛОГА (СООБЩЕНИЕ I)

https://doi.org/10.24884/1561-6274-2012-16-3/1-54-71

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Аннотация

В обзоре приводятся данные, касающиеся стресса эндоплазматического ретикулума (ЭПР-стресса). Приводятся сведения относительно биологической роли ЭПР-стресса, причин его возникновения, внутриклеточных событий, обеспечивающих развитие адаптивного и проапоптозного биохимических каскадов, лежащих в основе UPR, реакции на ЭПР-стресс, и определяющих судьбу клетки, подвергшейся воздействию этого стресса. Обсуждаются физиологические и патофизиологические аспекты ЭПР-стресса, его связь с гипоксией, воспалением, оксидативным стрессом. Рассматривается роль ЭПР-стресса в патогенезе ряда заболеваний.

Об авторах

Я. Ф. Зверев
Алтайского государственного медицинского университета
Россия

кафедра фармакологии

656038, г. Барнаул, пр. Ленина, д. 40. Тел.: (3852)26-08-35



В. М. Брюханов
Алтайского государственного медицинского университета
Россия
Кафедра фармакологии


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Для цитирования:


Зверев Я.Ф., Брюханов В.М. СТРЕСС ЭНДОПЛАЗМАТИЧЕСКОГО РЕТИКУЛУМА ГЛАЗАМИ НЕФРОЛОГА (СООБЩЕНИЕ I). Нефрология. 2012;16(3/1):54-71. https://doi.org/10.24884/1561-6274-2012-16-3/1-54-71

For citation:


Zverev Y.F., Bruhanov V.M. NEPHROLOGIST’S IMPRESSION OF ENDOPLASMATIC RETICULUM STRESS (TEXT 1). Nephrology (Saint-Petersburg). 2012;16(3/1):54-71. (In Russ.) https://doi.org/10.24884/1561-6274-2012-16-3/1-54-71

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