COMPARATIVE ASSESSMENT OF REACTIVITY OF THE VESSELS AS A FORM OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ATHEROSCLEROSIS AND CHRONIC KIDNEY DISEASE
https://doi.org/10.24884/1561-6274-2004-8-3-56-61
Abstract
THE AIM of the investigation was to compare vasomotor activity of blood vessels in patients with atherosclerosis and chronic kidney disease (CKD) with hyperlipidemia using electrophoretic tests with 0.2% solution of acetylcholine chloride (endotheliumdependent vasodilatation) and 1% solution of nitroglycerin (endotheliumindependent vasodilatation). PATIENTS AND METHODS. Tests with vasoactive substances were made in 20 patients with II stage obliterating atherosclerosis of lower extremities (OASLE) by Fontaine (mean age 56±6 years), 22 patients with CKD (mean age 45±3 years) and 20 healthy subjects (mean age 44±3 years). Microcirculation in the skin was assessed by the method of high frequency ultrasound dopplerography («MinimaxdopplerK», transducer with radiation frequency 25 MHz monitoring the tissue 5 mm deep). RESULTS. Patients with OASLE had impaired endothelium dependent vasodilatation, and patients with CKD had impaired both endotheliumdependent and endotheliumindependent vasodilatation. Changed reactivity was characteristic of microcirculation bed vessels not involved into the atherosclerotic process. CONCLUSION. OASLE and CKD are accompanied by systemic endothelial dysfunction. Changed reactivity of the vessels, at the level of the microcirculatory bed included, is considered to be manifestation of endothelial dysfunction.
About the Author
M. A. Menshutina
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Menshutina M.A. COMPARATIVE ASSESSMENT OF REACTIVITY OF THE VESSELS AS A FORM OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ATHEROSCLEROSIS AND CHRONIC KIDNEY DISEASE. Nephrology (Saint-Petersburg). 2004;8(3):56-61. (In Russ.) https://doi.org/10.24884/1561-6274-2004-8-3-56-61
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