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EFFECTS OF THYROXINE ON RENAL EXCRETION OF ENDOGENOUS NITRITES AND NITRATES IN WHITE RATS

https://doi.org/10.24884/1561-6274-2004-8-4-73-76

Abstract

THE AIM of the work was to study the influence of thyroxine on renal functions and renal excretion of nitrites and nitrates under conditions of osmotic load with solution of sodium chloride. MATERIALS AND METHODS. The investigation was carried out in white male rats, thyroxine was injected i/p 50 mkg/100 g body mass. Functions of the kidney were studied under conditions of induced diuresis after intragastric administration of water or 0.3%, 0.8%, 2% and 3% solutions of sodium chloride in volume 5% of body mass. RESULTS. It was found that thyroxin induced a decrease of creatinine clearance and elevated excreation of endogenous nitrites and nitrates. CONCLUSION. 1. Administration of thyroxin results in a stable decrease of glomerular filtration rate in all series of the experiments except load with 3% solution of sodium chloride. 2. Thyroxine exerts stimulating influence on renal excretion of nitrites and nitrates.

About the Authors

S. I. Dolomatov
Одесский государственный медицинский университет, Институт медико-биологических проблем РАН
Ukraine


A. I. Gozhenko
Одесский государственный медицинский университет, Институт медико-биологических проблем РАН
Ukraine


I. M. Larina
Одесский государственный медицинский университет, Институт медико-биологических проблем РАН
Ukraine


L. B. Buravkova
Одесский государственный медицинский университет, Институт медико-биологических проблем РАН
Ukraine


E. A. Dolomatova
Одесский государственный медицинский университет, Институт медико-биологических проблем РАН
Ukraine


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Review

For citations:


Dolomatov S.I., Gozhenko A.I., Larina I.M., Buravkova L.B., Dolomatova E.A. EFFECTS OF THYROXINE ON RENAL EXCRETION OF ENDOGENOUS NITRITES AND NITRATES IN WHITE RATS. Nephrology (Saint-Petersburg). 2004;8(4):73-76. (In Russ.) https://doi.org/10.24884/1561-6274-2004-8-4-73-76

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)