THE NUMIBER OF NEUTROPHIL CATIONIC PROTEINS AND EXPRESSION OF COMPLEMENTARY AND Fcγ-RECEPTORS ON THEIR MEMBRANE IN IgA-NEPHROPATHY
https://doi.org/10.24884/1561-6274-2003-7-3-67-71
Abstract
THEAIM of the investigation was to study the correlations of the quantitative and functional indices of the state of neutrophilic-granulocytic cells at IgA-nephropathy with the functional state of the kidneys and the biochemical composition of blood. PATIENTS AND METHODS. The investigation was performed in 15 IgA-nephropathy patients. The control group consisted of 21 patients with non-lgA mesangial-proliferative glomerulonephritis (Mes-PGN). The number of neutrophil cationic proteins was studied by the lysosomic-cationic test. Expression of erythrocytic, complementary and Fcg-receptors was investigated on the neutrophil membrane. RESULTS. The correlation of intensity of expression of the complementary and Fcy-receptors on the neutrophil membrane with the level of proteinuria was detected. CONCLUSION. The data obtained allow a suggestion that one of the mechanisms of the development of the glomerular filter in IgA-nephropathy might be a mechanism mediated by elevated exocytosis of cationic proteins of NG. C3b- and Fcy-receptors of NG might also be involved in injuring the glomerular filter in IgA-nephropathy. The mechanisms of injury of the renal tissue with NG in IgA-nephropathy differ from the mechanisms in Mes-PGN.
About the Authors
T. V. Abramova
Научно-исследовательский институт экспериментальной медицины РАМН,
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
E. G. Rybakina
Научно-исследовательский институт экспериментальной медицины РАМН,
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
I. G. Kayukov
Научно-исследовательский институт экспериментальной медицины РАМН,
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
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Review
For citations:
Abramova T.V., Rybakina E.G., Kayukov I.G. THE NUMIBER OF NEUTROPHIL CATIONIC PROTEINS AND EXPRESSION OF COMPLEMENTARY AND Fcγ-RECEPTORS ON THEIR MEMBRANE IN IgA-NEPHROPATHY. Nephrology (Saint-Petersburg). 2003;7(3):67-71. (In Russ.) https://doi.org/10.24884/1561-6274-2003-7-3-67-71
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