ROLE OF ANGIOTENSIN II IN THE DEVELOPMENT OF ARTERIAL HYPERTENSION WITH A LACK OF CALCIUM IN DIET
https://doi.org/10.24884/1561-6274-2003-7-4-81-84
Abstract
THEAIM of the work was to estimate the role of the development of arterial hypertension with a lack of calcium in diet. MATERIAL AND METHODS. Experiments were performed in narcotized rats in order to compare the influence of a synthetic analogue of parathyroid hypertensive factor on pressor effects of angiotensin Il and adrenaline. RESULTS. It was found that while potentiating and prolonging pressor effects of adrenaline, the parathyroid hypertensive factor blocks pressor effects of angiotensine II. The introduction of the parathyroid hypertensive factor against the background of effects of angiotensin Il results in paradoxically decreased arterial pressure. CONCLUSION. The results obtained confirm the hypothesis that renin-angiotensin-aldosteron system plays not less substantial role in the formation of calcium-dependent forms of arterial hypertension than the sympathoadrenal system.
About the Authors
N. Z. Klyueva
Институт физиологии им. акад. И.П.Павлова РАН;
Санкт-Петербургская медицинская академия последипломного образования
Russian Federation
Russian Federation
D. B. Ryzhov
Институт физиологии им. акад. И.П.Павлова РАН;
Санкт-Петербургская медицинская академия последипломного образования
Russian Federation
Russian Federation
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Review
For citations:
Klyueva N.Z., Ryzhov D.B. ROLE OF ANGIOTENSIN II IN THE DEVELOPMENT OF ARTERIAL HYPERTENSION WITH A LACK OF CALCIUM IN DIET. Nephrology (Saint-Petersburg). 2003;7(4):81-84. (In Russ.) https://doi.org/10.24884/1561-6274-2003-7-4-81-84
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