MITRAL REGURGITATION  IN  PATIENTS WITH  CHRONIC HEART FAILURE IS  ASSOCIATED WITH A DECLINED  FUNCTIONAL STATE OF THE  KIDNEYS

A. M. Shutov; E. V. Kurzina; V. A. Serov; T. N. Ivashkina

doi:10.24884/1561-6274-2008-12-1-19-23

MITRAL REGURGITATION IN PATIENTS WITH CHRONIC HEART FAILURE IS ASSOCIATED WITH A DECLINED FUNCTIONAL STATE OF THE KIDNEYS

A. M. Shutov, E. V. Kurzina, V. A. Serov, T. N. Ivashkina

https://doi.org/10.24884/1561-6274-2008-12-1-19-23

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Abstract

THE AIM of the investigation was to determine the relations between mitral regurgitation (MR) and glomerular filtration rate (GFR) in patients with chronic heart failure (CHF). PATIENTS AND METHODS. Under examination there were 340 patients with CHF (200 men and 140 women, mean age - 58±13 years). Arterial hypertension was the cause of CHF in 44 (13%) patients, IHD - in 112 (33%), their combination - in 184 (54%) patients. The first class of CHF was found in 112 (33%) patients, the second class - in 177 (52%), the third class - in 34 (10%), the fourth - in 17 (5%) patients. GFR was calculated by the Md RD formula. RESULTS. Ejection fraction (EF) of the left ventricle was 56.9±10.5%. Systolic dysfunction was diagnosed in 90 (26%) patients. Mitral regurgitation was observed in 221 (65%) patients. GFR was 68.8±20.9 ml/min/1.73 m² (from 19.2 to 149.7 ml/min/1.73 m²). In 114 (34%) patients GFR was lower than 60 ml/min/1.73 m². There was a direct relation between CHF FC and MR (r=0.35; p<0.001). Changes to the valve echostructure, cusp induration included, were noted in 228 (67%) patients. GFR had an inverse correlation with the MR degree (r=0.43; p<0.001). Multivariate regression analysis has shown that the degree of MR is associated with the declined functional state of the kidneys irrespective of the patients’ age. CONCLUSION. Changes to the mitral valve echostructure in patients with chronic heart failure due to IHD and/or arterial hypertension was more often observed in patients with GFR less than 60 ml/min/1.73 m². The degree of mitral regurgitation is directly associated with the decreased functional state of the kidneys.

Keywords

mitral regurgitation, chronic kidney disease, chronic heart failure

About the Authors

A. M. Shutov

Ульяновский государственный университет; Центральная городская клиническая больница, г. Ульяновск
Russian Federation

E. V. Kurzina

V. A. Serov

T. N. Ivashkina

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Review

For citations:

Shutov A.M., Kurzina E.V., Serov V.A., Ivashkina T.N. MITRAL REGURGITATION IN PATIENTS WITH CHRONIC HEART FAILURE IS ASSOCIATED WITH A DECLINED FUNCTIONAL STATE OF THE KIDNEYS. Nephrology (Saint-Petersburg). 2008;12(1):19-23. (In Russ.) https://doi.org/10.24884/1561-6274-2008-12-1-19-23

ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)

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