PREVALENCE OF DIABETIC NEPHROPATHY IN PATIENTS WITH ALLELE VARIANTS OF C677T POLYMORPHISM OF METHYLENETETRAHYDROFOLATE REDUCTASE GENE BY THE RESULTS OF 7-YEARS CATAMNESIS
https://doi.org/10.24884/1561-6274-2008-12-1-36-39
Abstract
THE AIM of the investigation was a 7-years catamnestic observation of patients with I type diabetes with different allele variants of the methylenetetrahydrofolate reductase (MTHFR) gene. PATIENTS AND METHODS. The investigation included 96 patients with different genotypes. RESULTS. The data obtained have shown the frequency of the development of diabetic nephropathy (DN) in patients with TT genotype (0.30) to be higher than in patients having genotype ОО (0.11) and CT (0.09) (p<0.05). CONCLUSION. The results of the investigation have confirmed that the genotype TT determination in patients with I type diabetes mellitus can be used as one of criteria of prediction of the development of DN in clinical practice.
About the Authors
Zh. V. Shutskaya
Городской диабетологический центр для детей и подростков;
Санкт-Петербургская государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
E. V. Bashnina
Городской диабетологический центр для детей и подростков;
Санкт-Петербургская государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
N. D. Savenkova
Городской диабетологический центр для детей и подростков;
Санкт-Петербургская государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
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Review
For citations:
Shutskaya Zh.V., Bashnina E.V., Savenkova N.D. PREVALENCE OF DIABETIC NEPHROPATHY IN PATIENTS WITH ALLELE VARIANTS OF C677T POLYMORPHISM OF METHYLENETETRAHYDROFOLATE REDUCTASE GENE BY THE RESULTS OF 7-YEARS CATAMNESIS. Nephrology (Saint-Petersburg). 2008;12(1):36-39. (In Russ.) https://doi.org/10.24884/1561-6274-2008-12-1-36-39
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