OXIDATIVE DAMAGE OF KIDNEY IN EXPERIMENTAL OXALATE NEPHROLITHIASIS

Abstract

THE AIM of the study was a comparison of the structural adjustment of the kidneys in nephrolithiasis with indicators of free-radical oxidation in blood and tissues of the kidneys. MATERIAL AND METHODS. The experiment was performed on Wistar rats, treated as a drinking a 1% aqueous solution of ethylene glycol for 42 days. Morphologically in the kidney sections was assessed changes in the kidney medulla, especially the distribution of calcium deposits, the location of the connective tissue elements. Biochemical methods evaluated oxidative and antioxidative status of kidneys and blood. RESULTS. In the course of the experiment in slices of kidney calcium deposition was observed in the renal papilla with the growth of connective tissue. The development of nephrolithiasis associated with activation of free-radical oxidation of the kidneys and blood, and the weakening of antioxidant defense due to the inhibition of glutathione peroxidase. CONCLUSION. Thus, when modeling urolithiasis we noted a direct correlation between the activation of free-radical oxidation in the development of oxalate nephrolithiasis.