Particular risk factors for chronic kidney disease in patients with chronic obstructive pulmonary disease
Abstract
AIM: to study chronic kidney disease (CKD) risk factors prevalence and reduced glomerular filtration rate (GFR) in patients with chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS. CKD risk factors (RF) retrospective analysis was performed in 300 pulmonary department patients with COPD. Glomerular filtration rate (GFR) was calculated using the formula CKD-EPI. RESULTS. CKD rF were revealed in all COPD patients, the combination of 3 or more RF in 92.6% of patients. The initial degree of GFRCKD-EPI reduction 89 - 60 ml/min /1.73 m2 - 37.3%, a moderate decrease GFRCKD-EPI 59 - 45 ml / min / 1.73 m2 - 26.7%, a significant reduction GFRCKD-EPI 44 - 30 ml / min / 1.73 m2 were 3.3% of patients. Direct moderate strength correlation between CKD RF prevalence and COPD severity was found. Negative correlation between GFRCKD-EPI and COPD severity, as well as between CKD-EPI and BMI was found. CONCLUSIONS. High prevalence of potentially modifiable risk factors among patients with COPD determines the need for CKD screening in these patients, as well as search for alternative markers for renal dysfunction early diagnosis in patients with severe and very severe COPD.
About the Authors
E. V. Bolotova
Kuban State Medical University
Russian Federation
Russian Federation
A. V. Dudnikova
Kuban State Medical University; regional clinical hospital №2
Russian Federation
Russian Federation
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Review
For citations:
Bolotova E.V., Dudnikova A.V. Particular risk factors for chronic kidney disease in patients with chronic obstructive pulmonary disease. Nephrology (Saint-Petersburg). 2015;19(5):28-33. (In Russ.)
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