CLINICAL FACTORS ASSOCIATED WITH THE OCCURENCE OF EARLY STAGES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH DIABETES MELLITUS TYPE 1
Abstract
THE AIM. The study was aimed to evaluate factors associated with early stages of chronic kidney disease (CKD) determined as albuminuria (AU) and estimated glomerular filtration rate (GFR) >60 ml/min/1,73 m2 in patients (pts) with diabetes mellitus type 1 (DMT1). PATIENTS AND METHODS. 192 diabetic pts with AU <60 mg/24h and GFR > 60 ml/min/1,73 m2 were included in this retrospective study. A number of clinical variables were studied. The presence of the early CKD stages was defined as AU 15-59 mg/24h. RESULTS. 46 pts (24%) had. The presence of neuropathy and decrease of hemoglobin (or presence of anemia) were independent predictors associated with higher urinary albumin excretion in linear regression model. The relative risk of AU 15-59 mg/24h associated with neuropathy, increase of glycated haemoglobin (HbA1C) and GFR. CONCLUSION. Monitoring of diabetic neurologic complications, metabolic control as well as GFR and hemoglobin in type 1 diabetic pts seems to be useful for early CKD risk evaluation and prevention.
About the Authors
V. A. Dobronravov
Research Institute of Nephrology; Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
O. V. Galkina
Research Institute of Nephrology
Russian Federation
Russian Federation
I. M. Zubina
Research Institute of Nephrology
Russian Federation
Russian Federation
A. V. Smirnov
Research Institute of Nephrology; Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Dobronravov V.A., Galkina O.V., Zubina I.M., Smirnov A.V. CLINICAL FACTORS ASSOCIATED WITH THE OCCURENCE OF EARLY STAGES OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH DIABETES MELLITUS TYPE 1. Nephrology (Saint-Petersburg). 2015;19(6):9-13. (In Russ.)
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