THE EFFICACY OF COMBINED BIOREGULATORY TREATMENT (PROSTATILEN + TIMOGEN) IN PATIENTS WITH INFECTIOUS CHRONIC PROSTATITIS

THE AIM: To evaluate the efficacy of combined use of prostate gland and thymus peptides in infectious chronic prostatitis (CP). PATIENTS AND METHODS: 63 patients aged 23 to 48 years were divided into three groups. In the 1st group (18 patients) patients were administered intramuscularly thymogen 100.0 mg/day. Patients in group 2 (21) received 30 mg prostatilen in suppositories with Dimexidum at night, and patients of the 3rd group (24 patients) received the combined treatment (prostatilen + timogen). Before and after treatment, patients were examined with prostate ultrasound, uroflowmetry, bacteriological examination of prostatic secretions. Symptoms of disease were assessed by International scale IPSS, patients quality of life (Ql) was analyzed. RESULTS: In patients from Group 1 inverse dynamics of clinical symptoms and prostate volume were less pronounced in comparison with the 2nd and 3rd groups. Total score of symptoms by IPSS decreased in patients from group 2 with 16,2 ± 2,3 to 12,4 ± 2,4 (p <0.05) and in patients from group 3 with 17,4 ± 3,1 to 12,1 ± 2,2. At the same time quality of life index in patients from 2nd and 3rd groups decreased from 5,0 ± 0,3 to 1,8 ± 0,4 (p <0.01) and 5,3 ± 1,1 to 2,1 ± 0,5 points (p <0.01), respectively. Prostate volume in patients from 2nd and 3rd groups decreased from 51,4 ± 5,5 cm3 to 47,2 ± 5,4 cm3 and 49,2 ± 4,6 cm3 to 45,4 ± 3,4 cm3, respectively, and the maximum urinary flow rate increased from 11,7 ± 2,4 ml/sec to 16,6 ± 2,8 ml/sec (p <0.05) in patients from group 2 with 12,7 ± 3,4 ml/sec to 18,4 ± 2,8 ml/sec (p <0.05) in patients from the 3rd group. CONCLUSION: The use of combined treatment (prostatilen with timogen) showed more pronounced regression of clinical symptoms, which is associated with a more profound impact on the pathogenesis of prostatitis and immune homeostasis.

infectious chronic prostatitis, peptides, pathogenesis, prostatilen, combination therapy

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