CARDIOVASCULAR RISK FACTORS IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION AND RENAL DYSFUNCTION IN DIFFERENT SEASONS OF A YEAR

THE AIM. Investigation of cardiovascular diseases (CVD) risk factors prevalence in men under 60 years old with myocardial infarction (MI) and renal dysfunction depending on a year season for enhanced prevention and treatment management of aforementioned target population.

PATIENTS AND METHODS. In-patient treatment results analyses of 412 men in total under 60 y.o. with MI for the period of 2000-2015 indicated that within primary 48 hours from the MI onset 61 patients were having 30-59 mL/min/1,73 m2 estimated glomerular filtration rate (CKD-EPI 2009, modification 2011) and 351 patients were having more than 60 mL/min/1,73 m2 respectively. Collection of supplemental information about MI promotive conditions and disease triggers was done with their manifestation rate comparison in groups of patients with renal dysfunction (RD) and normal CKDEPI. Seasonal differences evaluation was performed with separation of events by climatic time intervals based on mean daily air temperature changes in St. Petersburg, Russia.

RESULTS. RD was observed in 14.8% of the examined cases. The frequency of its detection prevailed in the spring and winter (22% each) seasons. Arterial hypertension (AH), mild obesity, hypertensive crisis events, frequent colds occurrences were noted to be detected more frequently in patients with the RD. Moderate obesity along with Ischemic Heart Disease (IHD) manifestations depending from a year season were noted less frequently. In first hours from a MI onset, RD patients demonstrated expressed dyslipidemia evidences due to hypertriglyceridemia and elevated levels of very low density lipoproteins (VLDL).

CONCLUSIONS. AH was noted to be the main cause of DP in men under 60 years old in their initial hours from the IM onset. Its presence in combination with frequent colds predisposition, regardless of diabetes and obesity presence in spring and winter attributes RD development risk in MI acute period. Dyslipidemia is indicative for this type of patients, and that brings the need to assess triglyceride and VLDL blood levels.

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