Clinical evaluation of indicators of respiratory function in patients with stage 5 chronic kidney disease

Background. Chronic kidney disease affects almost all organ systems. Respiratory lesions in these patients are often underestimated in clinical practice. THE AIM. Diagnosis and clinical evaluation of the respiratory system in patients with high-flux hemodialysis to optimize the treatment of patients with chronic kidney disease.

Patients and methods. There were 60 patients examined. Two groups were considered: the main group - patients with chronic glomerulonephritis (in 17 patients, the diagnosis was confirmed morphologically) with stage 5 chronic kidney disease (CKD), receiving hemodialysis therapy (n = 30), and the comparison group - patients not receiving dialysis (n = 30). Experience of smoking, results of clinical, biochemical blood tests and respiratory tests - vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC and maximum voluntary ventilation (MVV) were studied in all patients.

Results. The mean body mass index (BMI) in the main group of patients was 28 ± 6 kg/m², and in the comparison group, the average BMI was 24 ± 3 kg/m². BMI in groups as a whole was not significantly different (p = 0.40). In the general group, 29% had an increased level of triglycerides. No significant differences were found between the results of the respiratory tests of the two group (p>0.05).

Conclusion. FVC decreases in women receiving hemodialysis treatment; there is a decrease in FEV1/FVC in proportion to the duration of hemodialysis treatment in men. Increasing levels of C-reactive protein in patients on hemodialysis accompanied by a decrease in FVC; an increase in triglyceride levels accompanied by a decrease in the FEV1/FVC index.

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