IgM nephropathy in children: clinical, immunological, pathomorphological features
https://doi.org/10.24884/1561-6274-2019-23-5-71-76
Abstract
BACKGROUND. Studies on the problem of IgM nephropathy in children in the world literature are few. Data on the disease in adults and children In Belarus have not previously been presented.
THE AIM: to analyze the clinical, immunological, morphological characteristics, treatment regimen and prognostic factors of IgM nephropathy in children.
PATIENTS AND METHODS. The study included 153 patients during the 6 years observed in the Republican Center for Pediatric Nephrology, among whom 21 were diagnosed with IgM nephropathy.
RESULTS. Analysis of clinical, morphological features, the participation of markers of activation of T- and B-lymphocytes, pro-inflammatory and profibrotic molecules was performed.
CONCLUSIONS. In most cases, IgM nephropathy is characterized by steroid dependence or resistance, or frequent relapses, which dictates the need to join cytostatic agent. In childhood is characterized by a benign course with no signs of progression.
About the Authors
I. A. Kazyra
Belarussian State Medical University
Belarus
Belarus
Ina A. Kazyra - Associate Professor, MD, PhD, 1st Department of Pediatrics.
220116, Belarus, Minsk, av. Dzerzhynskogo 83.
Phone: (37517)3695761.
A. V. Sukalo
Belarussian State Medical University
Belarus
Belarus
Alexander V. Sukalo - Prof., Academic, MD, PhD, DMedSci, 1st Department of Pediatrics, Cheif.
220116, Belarus, Minsk, av. Dzerzhynskogo 83.
Phone: (37517)3695761.
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Review
For citations:
Kazyra I.A., Sukalo A.V. IgM nephropathy in children: clinical, immunological, pathomorphological features. Nephrology (Saint-Petersburg). 2019;23(5):71-76. (In Russ.) https://doi.org/10.24884/1561-6274-2019-23-5-71-76
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